Ace angiotensin I converting enzyme [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Aceprovided by RGD
Full Name: angiotensin I converting enzymeprovided by RGD
Primary source: RGD:2493
See related: Ensembl:ENSRNOG00000062101 AllianceGenome:RGD:2493
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcp1; CD143; StsRR92
Summary: Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 989.5), Testes (RPKM 175.9) and 2 other tissues See more
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Genomic context

Location:: 10q32.1

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91410129..91430246)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (90910316..90930437)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94170766..94213831)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE and ACE2 catalytic activity in the fecal content along the gut.
Title: ACE and ACE2 catalytic activity in the fecal content along the gut.
Increasing angiotensin-converting enzyme 1 regulated by histone 3 lysine 27 hyperacetylation in high-fat diet-induced hypertensive rat kidney.
Title: Increasing angiotensin-converting enzyme 1 regulated by histone 3 lysine 27 hyperacetylation in high-fat diet-induced hypertensive rat kidney.
ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants.
Title: ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants.
reatment with Cap decreased the expression levels of ACE, Ang II and AT1, and increased the expression levels of ACE2, Ang (1-7) and Mas. These findings suggested that an imbalance between ACE-Ang II-AT1 axis and ACE2-Ang (1-7)-Mas axis may participate in the development of silicosis.
Title: Dynamic Variation of RAS on Silicotic Fibrosis Pathogenesis in Rats.
brown Norway rats are a novel model of pregnancy complications in association with genetically controlled, increased ACE activity
Title: A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity.
ascorbic acid is able to prevent hypertension in offspring from prenatal inflammation exposure through ACE1 downregulation
Title: Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring.
Data suggest that angiotensin converting enzyme 1 within median preoptic nucleus plays a critical role in the sustained hypertension seen in chronic intermittent hypoxia.
Title: Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension.
Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure.
Title: Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.
Compared to chymase, ACE-mediated angiotensin-(1-12) metabolism in the heart was several fold lower. Overall our findings suggest that angiotensin-(1-12), not Ang I, is the better substrate for Ang II formation by chymase in adult rats.
Title: Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme.
Pomegranate peel extract consumption conferred protection against hypertension in the spontaneously hypertensive rat model. This finding was demonstrated by marked reduction in coronary ACE activity, oxidative stress, and vascular remodelling.
Title: Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats.

Submit: New GeneRIF Correction See all GeneRIFs (85)

General gene information

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Markers

D10Wox18 (e-PCR)
- UniSTS:118139

D10Mit1 (e-PCR), detects polymorphism
- UniSTS:118141

RH94768 (e-PCR)
- UniSTS:120015

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor binding	IEA Inferred from Electronic Annotation more info
enables bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables chloride ion binding	IEA Inferred from Electronic Annotation more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables exopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-dipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tripeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables tripeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis involved in coronary vascular morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin maturation	IEA Inferred from Electronic Annotation more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in angiotensin maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in bradykinin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bradykinin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in bradykinin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bradykinin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in bone marrow	IEA Inferred from Electronic Annotation more info
involved_in cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
involved_in hormone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gap junction assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil mediated immunity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-cysteine S-nitrosylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-cysteine S-nitrosylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to laminar fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in substance P catabolic process	IEA Inferred from Electronic Annotation more info
involved_in substance P catabolic process	ISO Inferred from Sequence Orthology more info
involved_in substance P catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: angiotensin-converting enzyme

Names: Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); angiotensin 1 converting enzyme 1; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme-like; dipeptidyl carboxypeptidase I; kininase II

NP_036676.1

EC 3.4.15.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.