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Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24298, updated on 11-Apr-2024

Summary

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Official Symbol
Cyp21a1provided by RGD
Official Full Name
cytochrome P450, family 21, subfamily a, polypeptide 1provided by RGD
Primary source
RGD:2461
See related
Ensembl:ENSRNOG00000000428 AllianceGenome:RGD:2461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
21-OH; Cyp21
Summary
Enables steroid 21-monooxygenase activity. Involved in cellular hormone metabolic process; cellular response to peptide hormone stimulus; and response to antibiotic. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 17893.1) See more
Orthologs
human mouse all
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Genomic context

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See Cyp21a1 in Genome Data Viewer
Location:
20p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4028323..4031549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4020217..4026923)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4486213..4489358, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene complement C4A Neighboring gene tenascin XA, pseudogene 1 Neighboring gene uncharacterized LOC134483856 Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Steroid 21-hydroxylase expression in cultured rat astrocytes. Lovelace M, et al. Brain Res Bull, 2003 Oct 15. PMID 14519458
  2. Congenital adrenal hyperplasia. Speiser PW, et al. N Engl J Med, 2003 Aug 21. PMID 12930931
  3. Cloning of two alternatively spliced 21-hydroxylase CDNAs from rat adrenal. Zhou MY, et al. J Steroid Biochem Mol Biol, 1997 Jul. PMID 9408081
  4. Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin. Brake PB, et al. Endocrinology, 1995 Nov. PMID 7588239
  5. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, et al. Toxicol Lett, 2009 Dec 15. PMID 19733641

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 17-hydroxyprogesterone 21-hydroxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables progesterone 21-hydroxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables steroid 21-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid 21-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucocorticoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mineralocorticoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in progesterone metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
steroid 21-hydroxylase
Names
21-OHase
Cytochrome P450 subfamily XXI (steroid 21-hydroxylase)
P-450c21
P450-C21
cytochrome P-450c21
cytochrome P450 21 steroid 21 hydroxylase
cytochrome P450 XXI
cytochrome P450, subfamily 21A, polypeptide 1
cytochrome P450, subfamily XXI (steroid 21-hydroxylase)
cytochrome P450-C21
NP_476442.2
XP_006255969.1
XP_063135021.1
XP_063135022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057101.2 → NP_476442.2  steroid 21-hydroxylase

    Status: VALIDATED

    Source sequence(s)
    BX883044
    UniProtKB/Swiss-Prot
    Q64562
    UniProtKB/TrEMBL
    F1LRG0
    Related
    ENSRNOP00000037516.3, ENSRNOT00000031548.4
    Conserved Domains (1) summary
    pfam00067
    Location:31 → 474
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4028323..4031549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278952.1 → XP_063135022.1  steroid 21-hydroxylase isoform X3

  2. XM_063278951.1 → XP_063135021.1  steroid 21-hydroxylase isoform X2

  3. XM_006255907.4 → XP_006255969.1  steroid 21-hydroxylase isoform X1

    UniProtKB/Swiss-Prot
    Q64562
    Conserved Domains (1) summary
    pfam00067
    Location:31 → 473
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64562.1 GenPept UniProtKB/Swiss-Prot:Q64562

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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