Cebpb CCAAT/enhancer binding protein beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cebpbprovided by RGD
Official Full Name: CCAAT/enhancer binding protein betaprovided by RGD
Primary source: RGD:2327
See related: AllianceGenome:RGD:2327
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TCF5; Il6dbp; NF-IL6
Summary: This intronless gene encodes a member of the transcription factor family whose members contain a basic leucine-zipper domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. The encoded protein plays important roles in several cellular processes and in various diseases, including regulating cell proliferation, differentiation, apoptosis and neuroinflammation, and being involved in brain injury and inflammatory progression. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with different cellular localizations and distinct biological functions. [provided by RefSeq, Sep 2014]
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176817005..176818436)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156398035..156399466)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164424502..164425933)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease.
Title: Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease.
P53 regulates CCAAT/Enhancer binding protein beta gene expression.
Title: P53 regulates CCAAT/Enhancer binding protein β gene expression.
CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
Title: CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPbeta.
Title: Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.
MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
Title: MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.
CEBPbeta regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
Title: CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
Metabolic impairment in response to early induction of C/EBPbeta leads to compromised cardiac function during pathological hypertrophy.
Title: Metabolic impairment in response to early induction of C/EBPβ leads to compromised cardiac function during pathological hypertrophy.
CCAAT/Enhancer-Binding Protein beta Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
Title: CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
miR-155 is a sustainable factor for intervertebral disk and suppresses the expression of catabolic genes induced by TNF-alpha and IL-1beta by targeting C/EBPbeta in rat nucleus pulposus cells.
Title: MicroRNA-155 suppresses the catabolic effect induced by TNF-α and IL-1β by targeting C/EBPβ in rat nucleus pulposus cells.
The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-beta-mediated cell death according to the apoptotic scenario.
Title: Combined Irradiation by Gamma Rays and Carbon Nuclei Increases the C/EBP-β LIP Isoform Content in the Pituitary Gland of Rats.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC316377P2 (e-PCR)
- UniSTS:272969

Cebpb (e-PCR), detects polymorphism
- UniSTS:547197

PMC114562P2 (e-PCR)
- UniSTS:270270

PMC21741P1 (e-PCR)
- UniSTS:272066

PMC55812P1 (e-PCR)
- UniSTS:273354

PMC55812P2 (e-PCR)
- UniSTS:273355

Cebpb (e-PCR), detects polymorphism
- UniSTS:532448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 1 cell activation	ISO Inferred from Sequence Orthology more info
involved_in T-helper 1 cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in granuloma formation	ISO Inferred from Sequence Orthology more info
involved_in granuloma formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of biomineral tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IC Inferred by Curator more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of odontoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of C/EBP complex	IEA Inferred from Electronic Annotation more info
part_of C/EBP complex	ISO Inferred from Sequence Orthology more info
part_of CHOP-C/EBP complex	IEA Inferred from Electronic Annotation more info
part_of CHOP-C/EBP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CHOP-C/EBP complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: CCAAT/enhancer-binding protein beta

Names: C/EBP beta; CCAAT/enhancer binding protein (C/EBP), beta; IL-6DBP; SF-B; interleukin-6-dependent-binding protein; nuclear factor-IL6; silencer factor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301715.1 → NP_001288644.1 CCAAT/enhancer-binding protein beta isoform LAP2

See identical proteins and their annotated locations for NP_001288644.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [LAP2, also known as LAP (liver activating protein), p34 or CRP2 (c/EBP-related protein 2)] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform LAP2 has a shorter N-terminus, compared to isoform LAP1.

Source sequence(s)

BC129071, JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2R490

Conserved Domains (1) summary

cd14712
Location:198 → 265

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
NM_001301720.1 → NP_001288649.1 CCAAT/enhancer-binding protein beta isoform LIP

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [LIP (liver inhibitory protein) or p20] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform LIP has a shorter N-terminus, compared to isoform LAP1.

Source sequence(s)

BC129071, JAXUCZ010000003

UniProtKB/Swiss-Prot

P21272

Conserved Domains (1) summary

cd14712
Location:67 → 134

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
NM_024125.5 → NP_077039.3 CCAAT/enhancer-binding protein beta isoform LAP1

See identical proteins and their annotated locations for NP_077039.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (LAP1, also known as LAP* or p38) represented in this RefSeq results from translation initiation at the 5' most AUG start codon and is the longest isoform.

Source sequence(s)

BC129071, JAXUCZ010000003

UniProtKB/Swiss-Prot

A2VD03, P21272

UniProtKB/TrEMBL

A0A8L2R490

Conserved Domains (1) summary

cd14712
Location:219 → 286

bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain