C6 complement C6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C6provided by RGD
Official Full Name: complement C6provided by RGD
Primary source: RGD:2238
See related: Ensembl:ENSRNOG00000024115 AllianceGenome:RGD:2238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in positive regulation of apoptotic process. Located in extracellular space. Used to study end stage renal disease; glomerulonephritis; and proteinuria. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 978.1) and Lung (RPKM 85.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (55573596..55648857)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (53846028..53921279)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (54460333..54533801)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury.
Title: C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury.
The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
C6 deficiency did not lead to neuroprotection after status epilepticus
Title: Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death.
Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes.
Title: Complement inhibition accelerates regeneration in a model of peripheral nerve injury.
essential in the mechanism of hepatic ischemia/reperfusion injury
Title: The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury.
This study demonstrates that complement component 6 is not essential for the development of proteinuria in passive Heymann nephritis.
Title: Induction of passive Heymann nephritis in complement component 6-deficient PVG rats.
The membrane attack complex of complement induces caspase activation and apoptosis.
Title: The membrane attack complex of complement induces caspase activation and apoptosis.
Lung allografts from C6-deficient donors to C6(-) recipients survive 13-17 days, whereas allografts from C6-sufficient donors to C6(+) recipients are rejected with intense vascular infiltration and diffuse alveolar hemorrhage 7 days posttransplant.
Title: Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C6 (e-PCR), detects polymorphism
- UniSTS:532665

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of complement activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	IEA Inferred from Electronic Annotation more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C6

Names: complement component 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176074.4 → NP_788263.2 complement component C6 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q811M5

UniProtKB/TrEMBL

F1M7F7

Related

ENSRNOP00000029891.5, ENSRNOT00000033112.5

Conserved Domains (8) summary

cd00033
Location:644 → 700

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02831
Location:644 → 764

PHA02831; EEV host range protein; Provisional

smart00209
Location:568 → 612

TSP1; Thrombospondin type 1 repeats

cd00112
Location:142 → 173

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01823
Location:292 → 514

MACPF; MAC/Perforin domain

pfam19028
Location:28 → 78

TSP1_spondin; Spondin-like TSP1 domain

cl15278
Location:85 → 128

TSP_1; Thrombospondin type 1 domain

cl20168
Location:862 → 934

Kazal_3; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

55573596..55648857

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760747.4 → XP_008758969.2 complement component C6 isoform X1

UniProtKB/Swiss-Prot

Q811M5

UniProtKB/TrEMBL

F1M7F7

Conserved Domains (8) summary

cd00033
Location:644 → 700

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02831
Location:644 → 764

PHA02831; EEV host range protein; Provisional

smart00209
Location:568 → 612

TSP1; Thrombospondin type 1 repeats

cd00112
Location:142 → 173

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01823
Location:292 → 514

MACPF; MAC/Perforin domain

pfam19028
Location:28 → 78

TSP1_spondin; Spondin-like TSP1 domain

cl15278
Location:85 → 128

TSP_1; Thrombospondin type 1 domain

cl20168
Location:862 → 934

Kazal_3; Kazal-type serine protease inhibitor domain