C4a complement C4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: C4aprovided by RGD
Full Name: complement C4Aprovided by RGD
Primary source: RGD:620005
See related: Ensembl:ENSRNOG00000066573 AllianceGenome:RGD:620005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C4; C4b; C4-1
Summary: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 2395.8), Lung (RPKM 1314.3) and 7 other tissues See more
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Genomic context

Location:: 20p12

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4010306..4024707)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4005731..4020083)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (2651599..2678183, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study provides the first evidence that sustained selective EPAC activation leads to an increase in TRPC3 and C4 protein expression and induces a proarrhythmic SOCE-like activity in adult rat ventricular cardiomyocytes
Title: Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes.
The expression of the complement component C3f and complement component 4A have potential for use in post-transplant diagnosis of rejection.
Title: Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.
C3 and C4 may be involved in the immunopathology of allergic rhinitis.
Title: [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis].
MASP-2, C4, and C2 and their activation fragments have roles in complement activation via the lectin pathway
Title: Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway.
This study presents the genomic organization of the two C4 gene-containing modules and the expression of the two C4 genes in the rat (Rattus norvegicus).
Title: The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation	TAS Traceable Author Statement more info	PubMed
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic cell clearance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C4

Names: complement C4-like; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031504.3 → NP_113692.2 complement C4 precursor

See identical proteins and their annotated locations for NP_113692.2

Status: VALIDATED

Source sequence(s)

AY149995, CK600071, CO555571, CO564028, FM042803, FM045174

UniProtKB/Swiss-Prot

P08649, Q62895, Q8R403

UniProtKB/TrEMBL

A0A0G2JW12, Q6MG79

Related

ENSRNOP00000069699.2, ENSRNOT00000086027.2

Conserved Domains (8) summary

cd00017
Location:684 → 752

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:991 → 1310

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

cd03584
Location:1581 → 1735

NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...

pfam00207
Location:779 → 866

A2M; Alpha-2-macroglobulin family

pfam01835
Location:139 → 231

A2M_N; MG2 domain

pfam07677
Location:1474 → 1563

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1046 → 1312

A2M_comp; A-macroglobulin complement component

pfam07703
Location:475 → 608

A2M_N_2; Alpha-2-macroglobulin family N-terminal region