Agtr1a angiotensin II receptor, type 1a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agtr1aprovided by RGD
Official Full Name: angiotensin II receptor, type 1aprovided by RGD
Primary source: RGD:2070
See related: Ensembl:ENSRNOG00000018346 AllianceGenome:RGD:2070
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AT1; AT1A; AT1R; Agtr1
Summary: Enables D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cation homeostasis; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 267.1), Kidney (RPKM 183.8) and 7 other tissues See more
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Genomic context

Location:: 17p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (34383397..34435523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (34173446..34226892, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (35907102..35958136, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
Title: DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats.
Title: Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats.
Astrocytic AT1R deficiency ameliorates Abeta-induced cognitive deficits and synaptotoxicity through beta-arrestin2 signaling.
Title: Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
Angiotensin II type 1a receptor knockout ameliorates high-fat diet-induced cardiac dysfunction by regulating glucose and lipid metabolism.
Title: Angiotensin II type 1a receptor knockout ameliorates high-fat diet-induced cardiac dysfunction by regulating glucose and lipid metabolism.
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway.
Title: Selenium deficiency causes hypertension by increasing renal AT(1) receptor expression via GPx1/H(2)O(2)/NF-κB pathway.
Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats.
Title: Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats.
The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis.
Title: The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis.
The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.
Title: The AT-1 Angiotensin Receptor is Involved in the Autonomic and Neuroendocrine Responses to Acute Restraint Stress in Male Rats.
Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
Title: Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame.
Title: Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame.

Submit: New GeneRIF Correction See all GeneRIFs (286)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Arb4 (e-PCR), detects polymorphism
- UniSTS:226818

Agtr1a (e-PCR), detects polymorphism
- UniSTS:516680

D17Mco9 (e-PCR)
- UniSTS:239470

RH86639 (e-PCR)
- UniSTS:118136

UniSTS:256385 (e-PCR)
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256385

Agtr1a (e-PCR), detects polymorphism
- UniSTS:256386

RH94717 (e-PCR)
- UniSTS:119964

RH130649 (e-PCR)
- UniSTS:213933

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables angiotensin type I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin type I receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin type I receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin type II receptor activity	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain renin-angiotensin system	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood vessel diameter homeostasis by renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of renal output by angiotensin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in renin-angiotensin regulation of aldosterone production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in organelle outer membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: type-1 angiotensin II receptor A

Names: AT1 receptor A; angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1a; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030985.4 → NP_112247.2 type-1 angiotensin II receptor A

See identical proteins and their annotated locations for NP_112247.2

Status: PROVISIONAL

Source sequence(s)

BC078810

UniProtKB/Swiss-Prot

P25095, Q9QVS5

UniProtKB/TrEMBL

A6J7M4

Related

ENSRNOP00000034687.3, ENSRNOT00000038532.4

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

34383397..34435523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771594.4 → XP_008769816.1 type-1 angiotensin II receptor A isoform X1

See identical proteins and their annotated locations for XP_008769816.1

UniProtKB/Swiss-Prot

P25095, Q9QVS5

UniProtKB/TrEMBL

A6J7M4

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039095335.2 → XP_038951263.1 type-1 angiotensin II receptor A isoform X1

UniProtKB/Swiss-Prot

P25095, Q9QVS5

UniProtKB/TrEMBL

A6J7M4

Conserved Domains (1) summary

cd15192
Location:29 → 313

7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors