Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adh1cprovided by RGD
Official Full Name: alcohol dehydrogenase 1C (class I), gamma polypeptideprovided by RGD
Primary source: RGD:2044
See related: Ensembl:ENSRNOG00000012436 AllianceGenome:RGD:2044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adh; Adh1; Adh1a
Summary: Enables NAD binding activity; ethanol binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including acetaldehyde biosynthetic process; ethanol oxidation; and response to progesterone. Located in cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to human ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 4807.6) and Kidney (RPKM 876.2) See more
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229470703..229482291)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226797303..226808892)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243550655..243562243)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study provides evidence that the simultaneous increase of liver ADH and a reduction of ALDH activity by gene transfer could constitute a potential therapeutic strategy for the treatment of alcoholism.
Title: Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer.
ADH class I gene is progesterone-responsive in the uterus.
Title: Evidence for the expression of alcohol dehydrogenase class I gene in rat uterus and its up-regulation by progesterone.
A high ADH activity leads to low ethanol intake in animals.
Title: Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.
class I alcohol dehydrogenase is induced by sterol regulatory element-binding protein-1 in rat liver
Title: Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver.
Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization.
Title: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.
rat hepatic Class I ADH gene expression is regulated in vivo by ethanol in a mechanism involving the C/EBP site and the enhancer binding proteins beta and gamma
Title: Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins beta and gamma.
Cellular expression of Adh1 in the GI tract was studied.
Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
activity and expression in gastrointestinal tissue homogenates
Title: Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.
Alcohol dehydrogenase
Title: Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes.
Results revealed that kidney alcohol dehydrogenase activities increased significantly after ethanol administration, but the electrophoretic pattern of alcohol dehydrogenase isoforms was unmodified.
Title: Ethanol-induced alterations of the antioxidant defense system in rat kidney.

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General gene information

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Markers

AI233003 (e-PCR)
- UniSTS:260895

D2Mco31 (e-PCR)
- UniSTS:239449

RH94448 (e-PCR)
- UniSTS:119696

RH127331 (e-PCR)
- UniSTS:210641

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	TAS Traceable Author Statement more info	PubMed
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to steroid hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to testosterone	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alcohol dehydrogenase 1

Names: alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1 (class I); alcohol dehydrogenase 1 (class I), gamma polypeptide; alcohol dehydrogenase 1, complex; alcohol dehydrogenase A subunit

NP_062159.3

EC 1.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019286.4 → NP_062159.3 alcohol dehydrogenase 1

See identical proteins and their annotated locations for NP_062159.3

Status: VALIDATED

Source sequence(s)

BC062403, FQ218571, JAXUCZ010000002

UniProtKB/Swiss-Prot

P06757

UniProtKB/TrEMBL

Q8K571

Related

ENSRNOP00000069797.2, ENSRNOT00000085067.2

Conserved Domains (2) summary

cd08299
Location:3 → 376

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

COG1062
Location:8 → 376

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]