Grk1 G protein-coupled receptor kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grk1provided by MGI
Official Full Name: G protein-coupled receptor kinase 1provided by MGI
Primary source: MGI:MGI:1345146
See related: Ensembl:ENSMUSG00000031450 AllianceGenome:MGI:1345146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rk; Rhok; Gprk1
Summary: Predicted to enable rhodopsin kinase activity. Acts upstream of or within several processes, including photoreceptor cell morphogenesis; positive regulation of phosphorylation; and post-embryonic retina morphogenesis in camera-type eye. Located in photoreceptor outer segment. Is expressed in retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.93 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13455081..13471951)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13405081..13421951)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Title: Microglial G(i)-dependent dynamics regulate brain network hyperexcitability.
Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.
Title: Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.
We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo.
Title: Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.
The retinal phenotype of Grk1-/- mice is compromised by a Crb1 rd8 mutation.
Title: The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
Rods and cones share the same isoforms of recoverin and GRK1, and photoactivation also triggers a calcium decline in cones
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
Knockout of Unc119 partially reversed the transport defect of GRK1 in cone photoreceptors caused by deletion of Pde6d.
Title: Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.
rhodopsin kinase may modulate the decay of light-activated PDE*, which may be responsible for the quickening of response recovery in background light.
Title: Modulation of mouse rod response decay by rhodopsin kinase and recoverin.
Altering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude.
Title: Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
phototransduction does not play a direct role in the light-dependent dephosphorylation of GRK1.
Title: Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension.
Title: Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables rhodopsin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rhodopsin kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of opsin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of retinal rod cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rhodopsin kinase GRK1

Names: G-protein receptor kinase 1

NP_036011.3

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011881.3 → NP_036011.3 rhodopsin kinase GRK1

See identical proteins and their annotated locations for NP_036011.3

Status: VALIDATED

Source sequence(s)

AC130818, BC030304, BC096611

Consensus CDS

CCDS22112.1

UniProtKB/Swiss-Prot

Q9WVL4

UniProtKB/TrEMBL

G3X905, Q4V9Z9

Related

ENSMUSP00000033827.8, ENSMUST00000033827.8

Conserved Domains (2) summary

cd05608
Location:188 → 475

STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1

cl02565
Location:42 → 179

RGS; Regulator of G protein signaling (RGS) domain superfamily