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Mmp25 matrix metallopeptidase 25 [ Mus musculus (house mouse) ]

Gene ID: 240047, updated on 11-Apr-2024

Summary

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Official Symbol
Mmp25provided by MGI
Official Full Name
matrix metallopeptidase 25provided by MGI
Primary source
MGI:MGI:2443938
See related
Ensembl:ENSMUSG00000023903 AllianceGenome:MGI:2443938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMP20; MT6-MMP; Leukolysin; F730048C11Rik
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded precursor undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Expression
Broad expression in thymus adult (RPKM 2.6), mammary gland adult (RPKM 1.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 11.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23847289..23864006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23628315..23645269, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene THO complex 6 Neighboring gene tumor necrosis factor receptor superfamily, member 12a Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling. Soria-Valles C, et al. J Immunol, 2016 Jul 1. PMID 27259858
  2. Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-β3. Brown GD, et al. BMC Dev Biol, 2010 Sep 1. PMID 20809987, Free PMC Article
  3. Membrane-type matrix metalloproteinases: Their functions and regulations. Itoh Y. Matrix Biol, 2015 May-Jul. PMID 25794647
  4. Basement membrane remodelling regulates mouse embryogenesis. Kyprianou C, et al. Nature, 2020 Jun. PMID 32523119, Free PMC Article
  5. Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation. Newby AC. Matrix Biol, 2015 May-Jul. PMID 25636537

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hard palate development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033339.5 → NP_001028511.1  matrix metalloproteinase-25 isoform 1

    See identical proteins and their annotated locations for NP_001028511.1

    Status: REVIEWED

    Source sequence(s)
    AC154766
    Consensus CDS
    CCDS28452.1
    UniProtKB/Swiss-Prot
    Q3U435
    Related
    ENSMUSP00000024696.8, ENSMUST00000024696.9
    Conserved Domains (4) summary
    cd00094
    Location:368 → 562
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:170 → 334
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:170 → 334
    Peptidase_M10; Matrixin
    pfam01471
    Location:89 → 140
    PG_binding_1; Putative peptidoglycan binding domain

  2. NM_001320258.2 → NP_001307187.1  matrix metalloproteinase-25 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154766
    Conserved Domains (3) summary
    cd00094
    Location:157 → 351
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:2 → 123
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:2 → 123
    Peptidase_M10; Matrixin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23847289..23864006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317466.3 → XP_017172955.1  matrix metalloproteinase-25 isoform X1

    Conserved Domains (3) summary
    cd00094
    Location:262 → 456
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:64 → 228
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:5 → 34
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U435.1 GenPept UniProtKB/Swiss-Prot:Q3U435

Gene LinkOut

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