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Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 23972, updated on 21-Apr-2024

Summary

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Official Symbol
Papss2provided by MGI
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by MGI
Primary source
MGI:MGI:1330223
See related
Ensembl:ENSMUSG00000024899 AllianceGenome:MGI:1330223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bm; Sk2; AtpsU2; Atpsk2; 1810018P12Rik
Summary
Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Acts upstream of or within blood coagulation; bone development; and sulfate assimilation. Is expressed in several structures, including genitourinary system; heart; limb; sensory organ; and skeleton. Used to study spondyloepimetaphyseal dysplasia, Pakistani type. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 50.1), small intestine adult (RPKM 40.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C1; 19 27.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32573072..32644587)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32595669..32667187)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene multiple inositol polyphosphate histidine phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32786522-32786822 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32787156-32787457 Neighboring gene STARR-seq mESC enhancer starr_45951 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32828923-32829124 Neighboring gene STARR-positive B cell enhancer ABC_E7646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32830866-32830975 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways. Wang W, et al. PLoS One, 2012. PMID 22916269, Free PMC Article
  2. The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration. Hallgrímsson B, et al. Evol Dev, 2006 Jan-Feb. PMID 16409383
  3. Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis. Ford-Hutchinson AF, et al. Osteoarthritis Cartilage, 2005 May. PMID 15882565
  4. Growth parameters in the epiphyseal cartilage of brachymorphic (bm/bm) mice. Vanky P, et al. Calcif Tissue Int, 2000 May. PMID 10773105
  5. Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. Franzon VL, et al. Int J Biochem Cell Biol, 1999 May. PMID 10399321

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
    Title: Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
  2. Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome.
    Title: Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.
  3. The results suggest that PAPSS2 might regulate osteoblast ALP activity and cell mineralization, probably through Smads signal pathways.
    Title: PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.
  4. hypertrophic chondrocytes show a dramatic down-regulation of Papss2 mRNA expression, indicating an important role of the gene product for cartilage growth and development in the embryo
    Title: Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylylsulfate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate adenylyltransferase (ATP) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfate assimilation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate assimilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Names
PAPS synthase 2
brachymorphic
sulfurylase kinase 2
NP_001188399.1
NP_001347332.1
NP_035994.2
XP_006527127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201470.1 → NP_001188399.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162887, AK137675, BY224664
    Consensus CDS
    CCDS89376.1
    UniProtKB/TrEMBL
    A0A494B923, Q9QYS0
    Related
    ENSMUSP00000157455.2, ENSMUST00000235594.2
    Conserved Domains (3) summary
    cd00517
    Location:243 → 606
    ATPS; ATP-sulfurylase
    cd02027
    Location:43 → 193
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    TIGR00339
    Location:234 → 605
    sopT; ATP sulphurylase

  2. NM_001360403.1 → NP_001347332.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162887
    Consensus CDS
    CCDS89377.1
    UniProtKB/TrEMBL
    A0A494BB18, Q9QYS0
    Related
    ENSMUSP00000158330.2, ENSMUST00000236290.2
    Conserved Domains (2) summary
    cd00517
    Location:245 → 608
    ATPS; ATP-sulfurylase
    cd02027
    Location:45 → 195
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

  3. NM_011864.3 → NP_035994.2  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1

    See identical proteins and their annotated locations for NP_035994.2

    Status: VALIDATED

    Source sequence(s)
    AC162887
    Consensus CDS
    CCDS37960.1
    UniProtKB/Swiss-Prot
    O88428, Q5BKP4, Q9Z274
    UniProtKB/TrEMBL
    Q9QYS0
    Related
    ENSMUSP00000025833.7, ENSMUST00000025833.7
    Conserved Domains (3) summary
    cd00517
    Location:245 → 613
    ATPS; ATP-sulfurylase
    cd02027
    Location:45 → 195
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    TIGR00339
    Location:236 → 612
    sopT; ATP sulphurylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    32573072..32644587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527064.5 → XP_006527127.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

    UniProtKB/TrEMBL
    Q9QYS0
    Conserved Domains (2) summary
    cd00517
    Location:243 → 611
    ATPS; ATP-sulfurylase
    cd02027
    Location:43 → 193
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88428.2 GenPept UniProtKB/Swiss-Prot:O88428

Gene LinkOut

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