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Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 23971, updated on 5-Mar-2024

Summary

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Official Symbol
Papss1provided by MGI
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by MGI
Primary source
MGI:MGI:1330587
See related
Ensembl:ENSMUSG00000028032 AllianceGenome:MGI:1330587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SK1; Asapk
Summary
Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Acts upstream of or within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Predicted to be part of sulfate adenylyltransferase complex (ATP). Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 34.0), genital fat pad adult (RPKM 31.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 61.05 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (131270626..131349432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (131564764..131643671)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sphingomyelin synthase 2 Neighboring gene STARR-seq mESC enhancer starr_09007 Neighboring gene predicted gene, 36753 Neighboring gene predicted gene, 36863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:131227425-131227534 Neighboring gene predicted gene, 36917 Neighboring gene STARR-seq mESC enhancer starr_09009 Neighboring gene STARR-seq mESC enhancer starr_09010 Neighboring gene olfactory receptor 375, pseudogene 1 Neighboring gene predicted gene, 29865 Neighboring gene STARR-seq mESC enhancer starr_09011 Neighboring gene predicted gene, 29949

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. Deyrup AT, et al. J Biol Chem, 1998 Apr 17. PMID 9545271
  2. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. Singh B, et al. J Biol Chem, 2003 Jan 3. PMID 12414806
  3. Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm. Schröder E, et al. PLoS One, 2012. PMID 22242175, Free PMC Article
  4. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. Xu ZH, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679223
  5. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Kurima K, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671738, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data illustrate the functional importance of several highly conserved residues in the active site of phosphoadenosine phosphosulfate synthetase.
    Title: Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylylsulfate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylylsulfate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate adenylyltransferase (ATP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate adenylyltransferase (ATP) activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of sulfate adenylyltransferase complex (ATP) IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Names
PAPS synthase 1
sulfurylase kinase 1
NP_001276406.1
NP_001276407.1
NP_001276408.1
NP_001397506.1
NP_001397507.1
NP_001397508.1
NP_035993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289477.2 → NP_001276406.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

    See identical proteins and their annotated locations for NP_001276406.1

    Status: VALIDATED

    Source sequence(s)
    AC127686
    Consensus CDS
    CCDS80023.1
    UniProtKB/TrEMBL
    Q6NZM8
    Conserved Domains (2) summary
    cd00517
    Location:233 → 596
    ATPS; ATP-sulfurylase
    cd02027
    Location:33 → 183
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

  2. NM_001289478.2 → NP_001276407.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

    See identical proteins and their annotated locations for NP_001276407.1

    Status: VALIDATED

    Source sequence(s)
    AC127686
    Consensus CDS
    CCDS80023.1
    UniProtKB/TrEMBL
    Q6NZM8
    Related
    ENSMUSP00000142533.2, ENSMUST00000199878.5
    Conserved Domains (2) summary
    cd00517
    Location:233 → 596
    ATPS; ATP-sulfurylase
    cd02027
    Location:33 → 183
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

  3. NM_001289479.2 → NP_001276408.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform c

    See identical proteins and their annotated locations for NP_001276408.1

    Status: VALIDATED

    Source sequence(s)
    AC127686
    UniProtKB/TrEMBL
    Q3TUA8
    Conserved Domains (3) summary
    cd00517
    Location:185 → 548
    ATPS; ATP-sulfurylase
    cd02027
    Location:1 → 135
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    TIGR00339
    Location:164 → 547
    sopT; ATP sulphurylase

  4. NM_001410577.1 → NP_001397506.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC127686
    UniProtKB/TrEMBL
    Q6NZM8
    Related
    ENSMUSP00000142616.2, ENSMUST00000200527.5

  5. NM_001410578.1 → NP_001397507.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC127686
    UniProtKB/TrEMBL
    Q6NZM8

  6. NM_001410579.1 → NP_001397508.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC127686
    UniProtKB/TrEMBL
    Q6NZM8

  7. NM_011863.3 → NP_035993.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a

    See identical proteins and their annotated locations for NP_035993.1

    Status: VALIDATED

    Source sequence(s)
    AC127686
    Consensus CDS
    CCDS38641.1
    UniProtKB/Swiss-Prot
    Q3U647, Q60967
    Related
    ENSMUSP00000029666.10, ENSMUST00000029666.14
    Conserved Domains (3) summary
    cd00517
    Location:254 → 617
    ATPS; ATP-sulfurylase
    TIGR00339
    Location:233 → 616
    sopT; ATP sulphurylase
    pfam01583
    Location:51 → 205
    APS_kinase; Adenylylsulphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    131270626..131349432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60967.1 GenPept UniProtKB/Swiss-Prot:Q60967

Gene LinkOut

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