U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gucy1b2 guanylate cyclase 1, soluble, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 239134, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gucy1b2provided by MGI
Official Full Name
guanylate cyclase 1, soluble, beta 2provided by MGI
Primary source
MGI:MGI:2660873
See related
Ensembl:ENSMUSG00000021933 AllianceGenome:MGI:2660873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC-SB2; B930025B03
Summary
Predicted to enable ion binding activity. Predicted to be involved in cGMP-mediated signaling. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 D1; 14 33.21 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62610384..62693745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62372935..62456291, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene STARR-seq mESC enhancer starr_36897 Neighboring gene predicted gene, 41173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:62961404-62961513 Neighboring gene ribonuclease H2, subunit B Neighboring gene STARR-positive B cell enhancer ABC_E11572 Neighboring gene STARR-seq mESC enhancer starr_36900 Neighboring gene predicted gene, 46457 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:63044104-63044321 Neighboring gene predicted gene, 35468 Neighboring gene STARR-seq mESC enhancer starr_36901 Neighboring gene predicted gene, 41172 Neighboring gene predicted gene 4131

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2. Omura M, et al. Mol Cell Neurosci, 2015 Mar. PMID 25701815, Free PMC Article
  2. A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. Bleymehl K, et al. Neuron, 2016 Dec 21. PMID 27916458, Free PMC Article
  3. Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. Duranski MR, et al. Am J Physiol Heart Circ Physiol, 2006 Dec. PMID 16877550
  4. Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. Wang H, et al. J Mol Cell Cardiol, 2009 Aug. PMID 19345227, Free PMC Article
  5. Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Koike K, et al. Neuron, 2021 Aug 4. PMID 34186026

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low oxygen induces calcium influx in a subpopulation of olfactory epithelium neurons, and Gucy1b2 and Trpc2 are required for these responses.
    Title: A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.
  2. Gucy1b2 is a marker for type B cells in olfactory epithelium.
    Title: Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2.
  3. These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]
    Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
  4. These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways.
    Title: Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
guanylate cyclase soluble subunit beta-2
Names
soluble guanylyl cyclase beta2 subunit
NP_001191269.1
NP_766398.1
XP_006519048.2
XP_006519050.1
XP_006519051.1
XP_011243363.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204340.1 → NP_001191269.1  guanylate cyclase soluble subunit beta-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC129219, AC154805
    Consensus CDS
    CCDS56962.1
    UniProtKB/TrEMBL
    B2RQD5, E9Q6H0
    Related
    ENSMUSP00000128114.2, ENSMUST00000165651.8
    Conserved Domains (4) summary
    smart00044
    Location:498 → 688
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:525 → 707
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:83 → 244
    HNOB; Haem-NO-binding
    pfam07701
    Location:333 → 519
    HNOBA; Heme NO binding associated

  2. NM_172810.3 → NP_766398.1  guanylate cyclase soluble subunit beta-2 isoform 1

    See identical proteins and their annotated locations for NP_766398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK047129, BY391897
    Consensus CDS
    CCDS27190.1
    UniProtKB/TrEMBL
    B2RQD5, Q8BXH3
    Related
    ENSMUSP00000022501.4, ENSMUST00000022501.10
    Conserved Domains (4) summary
    smart00044
    Location:513 → 703
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:540 → 722
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:83 → 244
    HNOB; Haem-NO-binding
    pfam07701
    Location:348 → 534
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    62610384..62693745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245061.4 → XP_011243363.2  guanylate cyclase soluble subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    B2RQD5
    Conserved Domains (3) summary
    pfam00211
    Location:572 → 754
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:115 → 276
    HNOB; Haem-NO-binding
    pfam07701
    Location:380 → 566
    HNOBA; Heme NO binding associated

  2. XM_006518987.4 → XP_006519050.1  guanylate cyclase soluble subunit beta-2 isoform X3

    UniProtKB/TrEMBL
    Q6XE41
    Conserved Domains (3) summary
    pfam00211
    Location:459 → 641
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:267 → 453
    HNOBA; Heme NO binding associated
    pfam07700
    Location:2 → 163
    HNOB; Haem-NO-binding

  3. XM_006518988.2 → XP_006519051.1  guanylate cyclase soluble subunit beta-2 isoform X4

    UniProtKB/TrEMBL
    Q6XE41
    Conserved Domains (3) summary
    pfam00211
    Location:424 → 606
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:232 → 418
    HNOBA; Heme NO binding associated
    pfam07700
    Location:1 → 128
    HNOB; Haem-NO-binding

  4. XM_006518985.5 → XP_006519048.2  guanylate cyclase soluble subunit beta-2 isoform X2

    UniProtKB/TrEMBL
    B2RQD5
    Conserved Domains (3) summary
    pfam00211
    Location:572 → 754
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:115 → 276
    HNOB; Haem-NO-binding
    pfam07701
    Location:380 → 566
    HNOBA; Heme NO binding associated
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous