Capn10 calpain 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capn10provided by MGI
Official Full Name: calpain 10provided by MGI
Primary source: MGI:MGI:1344392
See related: Ensembl:ENSMUSG00000026270 AllianceGenome:MGI:1344392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Capn8; mKIAA1845
Summary: Predicted to enable SNARE binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including actin cytoskeleton reorganization; positive regulation of transport; and type B pancreatic cell apoptotic process. Acts upstream of or within positive regulation of type B pancreatic cell apoptotic process. Predicted to be located in several cellular components, including cell cortex; cytosol; and mitochondrion. Predicted to be active in cytoplasm. Is expressed in dorsal root ganglion and renal calyx. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 19.1), ovary adult (RPKM 16.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 D

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (92862130..92875670)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (92934408..92947948)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.
Title: Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of Na(V)1.2 and Na(V)1.6.
TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes.
Title: TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes.
Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B
Title: Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.
Capn10 plays an important role in regulating obesity and diabetes in mice.
Title: Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.
Calpain 10 levels specifically decrease in kidney tissues when renal function decreases.
Title: Calpain 10 is required for cell viability and is decreased in the aging kidney.
These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice.
Title: Mitochondrial calpain 10 activity and expression in the kidney of multiple species.
calpain-10 has a role in beta-cell survival and is suppressed by RyR2
Title: RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
Title: Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW049679 (e-PCR)
- UniSTS:178441

AI430010 (e-PCR)
- UniSTS:158834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calpain-10

Names: CANP 10; calcium-activated neutral proteinase 10; calpain 8

NP_035926.2

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011796.2 → NP_035926.2 calpain-10

See identical proteins and their annotated locations for NP_035926.2

Status: VALIDATED

Source sequence(s)

BB747799, BC010969, BI986964

Consensus CDS

CCDS15181.1

UniProtKB/Swiss-Prot

Q99J13, Q9ESK3, Q9WVF0

Related

ENSMUSP00000027488.5, ENSMUST00000027488.11

Conserved Domains (3) summary

smart00720
Location:338 → 488

calpain_III; calpain_III domain

cd00044
Location:8 → 319

CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

cd00214
Location:506 → 647

Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...