Akap6 A kinase anchor protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap6provided by MGI
Official Full Name: A kinase anchor protein 6provided by MGI
Primary source: MGI:MGI:3050566
See related: Ensembl:ENSMUSG00000061603 AllianceGenome:MGI:3050566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PRKA; Akapbeta; Akapalpha
Summary: Enables adenylate cyclase binding activity. Predicted to be involved in several processes, including positive regulation of cellular protein metabolic process; regulation of ion transmembrane transport; and regulation of muscle system process. Located in nuclear membrane and perinuclear region of cytoplasm. Is expressed in gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 7.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 22.18 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (52745371..53202351)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (52698588..53155568)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKAP6 interacts with PLN in HEK-293T and murine cardiomyocytes.
Title: AKAP6 and phospholamban colocalize and interact in HEK-293T cells and primary murine cardiomyocytes.
Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin.
Title: AKAP6 inhibition impairs myoblast differentiation and muscle regeneration: Positive loop between AKAP6 and myogenin.
These results identify mAKAPalpha as a scaffold for signaling in the stressed neuron that is required for RGC neuroprotection after optic nerve injury.
Title: Muscle A-Kinase Anchoring Protein-α is an Injury-Specific Signaling Scaffold Required for Neurotrophic- and Cyclic Adenosine Monophosphate-Mediated Survival.
The association of AC5 with the AKAP6 complex is required for the regulation of cAMP second messenger controlling cardiac myocyte hypertrophy.
Title: An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.
two alternatively spliced forms of mAKAP are expressed: mAKAPalpha, the longer form, and mAKAPbeta. mAKAPalpha is preferentially expressed in brain
Title: Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AI482140 (e-PCR)
- UniSTS:180392

D12Mit126 (e-PCR), detects polymorphism
- UniSTS:126680

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in junctional sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 6

Names: A kinase (PRKA) anchor protein 6; A-kinase anchoring protein alpha; A-kinase anchoring protein beta; anchor protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198111.2 → NP_932779.2 A-kinase anchor protein 6

See identical proteins and their annotated locations for NP_932779.2

Status: VALIDATED

Source sequence(s)

AK129115, AK147248, AK147371, BC057114, CT030137

Consensus CDS

CCDS36444.1

UniProtKB/TrEMBL

E9Q9K8, Q3UHI8

Related

ENSMUSP00000093406.4, ENSMUST00000095737.5

Conserved Domains (2) summary

cd00176
Location:958 → 1184

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 924

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

52745371..53202351

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515821.4 → XP_006515884.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515884.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515828.4 → XP_006515891.1 A-kinase anchor protein 6 isoform X2

See identical proteins and their annotated locations for XP_006515891.1

UniProtKB/TrEMBL

E9Q9K8, Q3UHI8

Conserved Domains (2) summary

cd00176
Location:958 → 1184

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 924

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515822.4 → XP_006515885.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515885.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017315055.2 → XP_017170544.1 A-kinase anchor protein 6 isoform X1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515826.5 → XP_006515889.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515889.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_030246699.2 → XP_030102559.1 A-kinase anchor protein 6 isoform X2

UniProtKB/TrEMBL

E9Q9K8, Q3UHI8

Conserved Domains (2) summary

cd00176
Location:958 → 1184

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 924

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515825.5 → XP_006515888.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515888.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515827.5 → XP_006515890.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515890.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515824.5 → XP_006515887.1 A-kinase anchor protein 6 isoform X1

See identical proteins and their annotated locations for XP_006515887.1

UniProtKB/TrEMBL

Q3UHI8

Conserved Domains (2) summary

cd00176
Location:959 → 1185

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:781 → 925

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006515829.5 → XP_006515892.1 A-kinase anchor protein 6 isoform X3

UniProtKB/TrEMBL

Q2VEB3

Conserved Domains (2) summary

cd00176
Location:715 → 941

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:537 → 681

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_030246700.2 → XP_030102560.1 A-kinase anchor protein 6 isoform X3

UniProtKB/TrEMBL

Q2VEB3

Conserved Domains (2) summary

cd00176
Location:715 → 941

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:537 → 681

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036157394.1 → XP_036013287.1 A-kinase anchor protein 6 isoform X4

UniProtKB/TrEMBL

Q2VEB3

Conserved Domains (2) summary

cd00176
Location:714 → 940

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:537 → 680

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036157393.1 → XP_036013286.1 A-kinase anchor protein 6 isoform X4

UniProtKB/TrEMBL

Q2VEB3

Conserved Domains (2) summary

cd00176
Location:714 → 940

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02488
Location:537 → 680

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...