Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts5provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 5provided by MGI
Primary source: MGI:MGI:1346321
See related: Ensembl:ENSMUSG00000022894 AllianceGenome:MGI:1346321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; 9530092O11Rik
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 15.5), genital fat pad adult (RPKM 13.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 48.34 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (85655045..85698013, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (85858157..85901125, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA demethylation of promoter region orchestrates SPI-1-induced ADAMTS-5 expression in articular cartilage of osteoarthritis mice.
Title: DNA demethylation of promoter region orchestrates SPI-1-induced ADAMTS-5 expression in articular cartilage of osteoarthritis mice.
Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
Title: Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy.
Title: ADAMTS5 promotes neovascularization via autophagic degradation of PEDF in proliferative diabetic retinopathy.
MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting Adamts5 in Skeletal Muscle Regeneration and Myogenesis.
Title: MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting Adamts5 in Skeletal Muscle Regeneration and Myogenesis.
The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency.
Title: The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency.
Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling.
Title: Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling.
ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle.
Title: ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle.
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.
Title: Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture.
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.
Title: Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Title: Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

32.MMHAP16FRC11.seq (e-PCR)
- UniSTS:123975

AI481094 (e-PCR)
- UniSTS:160589

Adamts5 (e-PCR), detects polymorphism
- UniSTS:495975

Adamts5 (e-PCR), detects polymorphism
- UniSTS:534409

Adamts5 (e-PCR), detects polymorphism
- UniSTS:534410

Adamts5 (e-PCR), detects polymorphism
- UniSTS:532652

Adamts5 (e-PCR), detects polymorphism
- UniSTS:259033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocardial cushion morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	TAS Traceable Author Statement more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pulmonary valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 5

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); aggrecanase-2; implantin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011782.2 → NP_035912.2 A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

See identical proteins and their annotated locations for NP_035912.2

Status: REVIEWED

Source sequence(s)

AC126936, AC163107, AK044746

Consensus CDS

CCDS28288.1

UniProtKB/Swiss-Prot

B2RRX9, Q9R001

Related

ENSMUSP00000023611.6, ENSMUST00000023611.7

Conserved Domains (6) summary

smart00209
Location:570 → 622

TSP1; Thrombospondin type 1 repeats

cd04273
Location:269 → 473

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:269 → 476

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:68 → 174

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:732 → 852

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:486 → 556

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

85655045..85698013 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159912.1 → XP_036015805.1 A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1

Conserved Domains (5) summary

smart00209
Location:132 → 184

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:294 → 414

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:49 → 116

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:441 → 492

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 35

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...