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Rbm41 RNA binding motif protein 41 [ Mus musculus (house mouse) ]

Gene ID: 237073, updated on 5-Mar-2024

Summary

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Official Symbol
Rbm41provided by MGI
Official Full Name
RNA binding motif protein 41provided by MGI
Primary source
MGI:MGI:2444923
See related
Ensembl:ENSMUSG00000031433 AllianceGenome:MGI:2444923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D330023I21Rik
Summary
Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. Is expressed in brain; cerebral cortex; hippocampus; and retina. Orthologous to human RBM41 (RNA binding motif protein 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.0), CNS E11.5 (RPKM 1.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Rbm41 in Genome Data Viewer
Location:
X F1; X 61.35 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138790260..138899344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139889511..139998595, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene claudin 2 Neighboring gene microrchidia 4 Neighboring gene predicted gene, 52431 Neighboring gene NMD3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_48000 Neighboring gene nucleoporin 62 C-terminal like Neighboring gene dynein axonemal assembly factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U12 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172147.1 → NP_001165618.1  RNA-binding protein 41 isoform 1

    See identical proteins and their annotated locations for NP_001165618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK164496, AL672270, BC037024, BY125116
    Consensus CDS
    CCDS53204.1
    UniProtKB/Swiss-Prot
    Q8JZV4
    Related
    ENSMUSP00000108631.2, ENSMUST00000113007.8
    Conserved Domains (2) summary
    COG0724
    Location:312 → 403
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:320 → 397
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  2. NM_001172148.1 → NP_001165619.1  RNA-binding protein 41 isoform 3

    See identical proteins and their annotated locations for NP_001165619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, uses an upstream start codon, and has a distinct terminal exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK166005, BY125116
    Consensus CDS
    CCDS53205.1
    UniProtKB/Swiss-Prot
    Q8JZV4
    Related
    ENSMUSP00000084662.6, ENSMUST00000087400.12
    Conserved Domains (2) summary
    COG0724
    Location:300 → 361
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:308 → 362
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001290630.1 → NP_001277559.1  RNA-binding protein 41 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and contains an alternate exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK084514, AK141075, AL672270, BY125116
    Consensus CDS
    CCDS72439.1
    UniProtKB/TrEMBL
    A2AG09
    Related
    ENSMUSP00000108634.3, ENSMUST00000113011.9
    Conserved Domains (2) summary
    COG0724
    Location:324 → 415
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:332 → 409
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  4. NM_153586.2 → NP_705814.1  RNA-binding protein 41 isoform 2

    See identical proteins and their annotated locations for NP_705814.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL672270, BC037024, BY125116
    Consensus CDS
    CCDS41147.1
    UniProtKB/Swiss-Prot
    A2AG07, Q3TMC8, Q3TPC6, Q8C9Y2, Q8JZV4
    Related
    ENSMUSP00000033810.8, ENSMUST00000033810.8
    Conserved Domains (2) summary
    COG0724
    Location:300 → 391
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12239
    Location:308 → 385
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    138790260..138899344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251329.2 → XP_030107189.1  RNA-binding protein 41 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:339 → 394
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_011247736.4 → XP_011246038.1  RNA-binding protein 41 isoform X1

    Conserved Domains (1) summary
    cd12239
    Location:339 → 416
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  3. XM_030251328.2 → XP_030107188.1  RNA-binding protein 41 isoform X2

    Conserved Domains (1) summary
    cd12239
    Location:315 → 392
    RRM2_RBM40_like; RNA recognition motif 2 in RNA-binding protein 40 (RBM40) and similar proteins

  4. XM_036161932.1 → XP_036017825.1  RNA-binding protein 41 isoform X4

    Conserved Domains (1) summary
    cd12239
    Location:123 → 200
    RRM2_RBM40_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 40 (RBM40) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZV4.1 GenPept UniProtKB/Swiss-Prot:Q8JZV4

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