NTSR2 neurotensin receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTSR2provided by HGNC
Official Full Name: neurotensin receptor 2provided by HGNC
Primary source: HGNC:HGNC:8040
See related: Ensembl:ENSG00000169006 MIM:605538; AllianceGenome:HGNC:8040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NTR2
Summary: The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward brain (RPKM 9.3) See more
Orthologs: mouse all
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Genomic context

Location:: 2p25.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (11658178..11670195, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (11691322..11703339, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (11798304..11810321, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
Title: Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia.
Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
Title: Physiological and Pathological Roles of NTSR2 in Several Organs and Diseases (Review).
Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
Title: Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications.
A novel role of NTS in the development of Castration-resistant prostate cancer with Neuroendocrine differentiation (NED), and a possible strategy to prevent the onset of NED by targeting the NTS signaling pathway.
Title: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.
High NTSR2 expression is associated with B-cell chronic lymphocytic leukemia.
Title: Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis.
We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.
Title: Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells
Title: Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells.
Title: Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
this study proposes a novel function of NTR2 in the regulation of NTR1 activity.
Title: Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.
NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)
Title: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled neurotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in sensory perception	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: neurotensin receptor type 2

Names: NT-R-2; levocabastine-sensitive neurotensin receptor; neurotensin receptor, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012344.4 → NP_036476.2 neurotensin receptor type 2

Status: REVIEWED

Source sequence(s)

AC106875, AC110754

Consensus CDS

CCDS1681.1

UniProtKB/Swiss-Prot

O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6

Related

ENSP00000303686.5, ENST00000306928.6

Conserved Domains (1) summary

cd15356
Location:33 → 369

7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

11658178..11670195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005246156.4 → XP_005246213.1 neurotensin receptor type 2 isoform X4

Conserved Domains (1) summary

pfam00001
Location:98 → 182

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_006711877.4 → XP_006711940.1 neurotensin receptor type 2 isoform X3

Conserved Domains (2) summary

cd14964
Location:35 → 59

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:33 → 233

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006711876.5 → XP_006711939.1 neurotensin receptor type 2 isoform X2

Conserved Domains (1) summary

pfam00001
Location:98 → 234

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_017003738.2 → XP_016859227.1 neurotensin receptor type 2 isoform X1