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FPR3 formyl peptide receptor 3 [ Homo sapiens (human) ]

Gene ID: 2359, updated on 5-Mar-2024

Summary

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Official Symbol
FPR3provided by HGNC
Official Full Name
formyl peptide receptor 3provided by HGNC
Primary source
HGNC:HGNC:3828
See related
Ensembl:ENSG00000187474 MIM:136539; AllianceGenome:HGNC:3828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FMLP-R-II; FML2_HUMAN
Summary
Predicted to enable N-formyl peptide receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in appendix (RPKM 15.7), gall bladder (RPKM 12.8) and 22 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51795157..51826190)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54882351..54913384)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52298410..52329443)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene formyl peptide receptor 2 Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene uncharacterized LOC105372448 Neighboring gene zinc finger protein 577 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:52350575-52351774 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Nawaz MI, et al. Angiogenesis, 2020 Aug. PMID 32152757
  2. Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors. Wang X, et al. Protein Pept Lett, 2013 Nov. PMID 23746112
  3. Transcriptional variations mediated by an alternative promoter of the FPR3 gene. Ha HS, et al. Mamm Genome, 2011 Oct. PMID 21717223
  4. F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling. Lee HY, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17577578
  5. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. Yang D, et al. J Leukoc Biol, 2002 Sep. PMID 12223529

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
    Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
  2. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
    Title: D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
  3. Low FPR3 expression is associated with obstructive sleep apnea.
    Title: Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.
  4. These findings provide evidence for defective FPR2/3 and annexin A1 expressions that, associated with decreased M2a polarization, might be involved in the development of cigarette smoking induced persistent airflow limitation in chronic obstructive pulmonary disease.
    Title: Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.
  5. Taken together, our results suggest that intracellular FPR in naive CD4 T cells and surface FPRs in activated CD4 T cells might regulate immune responses by regulating CD4 T cell activity.
    Title: Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.
  6. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis.
    Title: Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.
  7. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling.
    Title: Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.
  8. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution.
    Title: Transcriptional variations mediated by an alternative promoter of the FPR3 gene.
  9. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils
    Title: Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
  10. N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.
    Title: N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
N-formyl peptide receptor 3
Names
FMLP-related receptor II
formyl peptide receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002030.5 → NP_002021.3  N-formyl peptide receptor 3

    See identical proteins and their annotated locations for NP_002021.3

    Status: VALIDATED

    Source sequence(s)
    AI301735, AK123030, BC059388, CB996360, DA844883
    Consensus CDS
    CCDS12841.1
    UniProtKB/Swiss-Prot
    P25089
    UniProtKB/TrEMBL
    Q6L5J4
    Related
    ENSP00000341821.3, ENST00000339223.5
    Conserved Domains (2) summary
    cd14964
    Location:29 → 53
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 313
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51795157..51826190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526687.3 → XP_011524989.1  N-formyl peptide receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_011524989.1

    UniProtKB/Swiss-Prot
    P25089
    UniProtKB/TrEMBL
    Q6L5J4
    Related
    ENSP00000470471.1, ENST00000595991.1
    Conserved Domains (2) summary
    cd14964
    Location:29 → 53
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 313
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54882351..54913384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320417.1 → XP_054176392.1  N-formyl peptide receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    P25089
    UniProtKB/TrEMBL
    Q6L5J4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25089.2 GenPept UniProtKB/Swiss-Prot:P25089

Gene LinkOut

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