Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
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FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor. The gp120 V3 crown is an important determinant for the efficient FPRL1 usage by the type-C virus |
PubMed
|
|
env
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A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES |
PubMed
|
|
env
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A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R |
PubMed
|
Envelope transmembrane glycoprotein gp41
|
env
|
FPRL1 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor |
PubMed
|
|
env
|
Matriptase, a serine protease, efficiently cleaves the HR1 portion of HIV-1 gp41 into a 22-residue chemotactic peptide MAT-1, leading to chemotaxis by using FPR2 in primary neutrophils |
PubMed
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|
env
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HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5 |
PubMed
|
Go to the HIV-1, Human Interaction Database