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Ddx19b DEAD box helicase 19b [ Mus musculus (house mouse) ]

Gene ID: 234733, updated on 11-Apr-2024

Summary

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Official Symbol
Ddx19bprovided by MGI
Official Full Name
DEAD box helicase 19bprovided by MGI
Primary source
MGI:MGI:2148251
See related
Ensembl:ENSMUSG00000033658 AllianceGenome:MGI:2148251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810457M08Rik; 4921519L13Rik
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in nuclear envelope. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in orbito-sphenoid and turbinate bone primordium. Orthologous to human DDX19B (DEAD-box helicase 19B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 17.0), CNS E11.5 (RPKM 7.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.88 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111729818..111758383, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111003186..111031751, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene DEAD box helicase 19a Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene microRNA 3473d Neighboring gene STARR-positive B cell enhancer ABC_E566 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene exosome component 6 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. Zhang K, et al. Cell Rep, 2019 Jan 29. PMID 30699353
  2. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19B
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b
NP_001177715.1
NP_001177729.1
NP_758488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190786.1 → NP_001177715.1  ATP-dependent RNA helicase DDX19B isoform 1

    See identical proteins and their annotated locations for NP_001177715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK033235, AK147499, BC079644
    Consensus CDS
    CCDS57645.1
    UniProtKB/TrEMBL
    Q8BZY3
    Related
    ENSMUSP00000066806.6, ENSMUST00000065784.6
    Conserved Domains (3) summary
    PTZ00424
    Location:106 → 484
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:322 → 457
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:109 → 311
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001190800.1 → NP_001177729.1  ATP-dependent RNA helicase DDX19B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AC093451, AK013362, AK147499, BC079644
    UniProtKB/TrEMBL
    Q8R3C7
    Conserved Domains (3) summary
    smart00487
    Location:107 → 310
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:307 → 442
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:94 → 296
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_172284.5 → NP_758488.1  ATP-dependent RNA helicase DDX19B isoform 2

    See identical proteins and their annotated locations for NP_758488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093451, AK147499, BC079644
    Consensus CDS
    CCDS22669.1
    UniProtKB/TrEMBL
    Q8R3C7
    Related
    ENSMUSP00000038551.9, ENSMUST00000040241.15
    Conserved Domains (3) summary
    PTZ00424
    Location:91 → 469
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:307 → 442
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:94 → 296
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111729818..111758383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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