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Gys2 glycogen synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 232493, updated on 21-Apr-2024

Summary

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Official Symbol
Gys2provided by MGI
Official Full Name
glycogen synthase 2provided by MGI
Primary source
MGI:MGI:2385254
See related
Ensembl:ENSMUSG00000030244 AllianceGenome:MGI:2385254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LGS
Summary
Predicted to enable glucose binding activity and glycogen (starch) synthase activity. Predicted to be involved in glycogen biosynthetic process and response to glucose. Predicted to be located in cortical actin cytoskeleton; cytosol; and ectoplasm. Predicted to be active in cytoplasm. Is expressed in liver. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 32.0), liver adult (RPKM 14.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G2; 6 74.04 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142368339..142418856, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142422612..142473130, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene golgi transport 1B Neighboring gene spexin hormone Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:142438685-142438868 Neighboring gene STARR-seq mESC enhancer starr_17706 Neighboring gene lactate dehydrogenase B Neighboring gene STARR-seq mESC enhancer starr_17707 Neighboring gene predicted gene, 38919

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA. Zhang X, et al. Nat Commun, 2022 Nov 17. PMID 36396934, Free PMC Article
  2. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. Irimia JM, et al. J Biol Chem, 2017 Jun 23. PMID 28483921, Free PMC Article
  3. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Zani F, et al. Mol Metab, 2013. PMID 24049741, Free PMC Article
  4. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. von Wilamowitz-Moellendorff A, et al. Diabetes, 2013 Dec. PMID 23990365, Free PMC Article
  5. Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis. Ros S, et al. J Biol Chem, 2010 Nov 26. PMID 20841354, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
    Title: Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
  2. N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.
    Title: N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.
  3. These data show that G6P-mediated activation of GYS2 plays a key role in controlling glycogen synthesis and hepatic glucose-G6P flux control and thus whole-body glucose homeostasis.
    Title: Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis.
  4. A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies Gys2 as novel candidate obesity genes.
    Title: A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.
  5. Transgenic LGS mice showed enhanced glycogen storage and an mproved glucose tolerance.
    Title: Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.
  6. CLOCK regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
    Title: CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
  7. Mouse enzyme is a novel target of peroxisome proliferator-activated receptor, which is in turn mediated by two response elements.
    Title: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
  8. The endogenous glycogen synthase in extracts from mouse liver bound specifically to SAPK2b/p38b & was phosphorylated at residues Ser644, Ser652, Thr718 and Ser724.
    Title: Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC29379

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose binding ISO
Inferred from Sequence Orthology
more info
  
enables glycogen (starch) synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycogen (starch) synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycogen (starch) synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycogen [starch] synthase, liver
Names
glycogen synthase, liver
NP_001398553.1
NP_663547.2
XP_011239885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411624.1 → NP_001398553.1  glycogen [starch] synthase, liver isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142413

  2. NM_145572.3 → NP_663547.2  glycogen [starch] synthase, liver isoform 1

    See identical proteins and their annotated locations for NP_663547.2

    Status: VALIDATED

    Source sequence(s)
    AC142413
    Consensus CDS
    CCDS20683.1
    UniProtKB/Swiss-Prot
    Q3UTY0, Q8VCB3
    Related
    ENSMUSP00000032371.8, ENSMUST00000032371.8
    Conserved Domains (2) summary
    cd03793
    Location:27 → 615
    GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...
    pfam05693
    Location:32 → 657
    Glycogen_syn; Glycogen synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142368339..142418856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241583.2 → XP_011239885.1  glycogen [starch] synthase, liver isoform X2

    Conserved Domains (1) summary
    pfam05693
    Location:32 → 355
    Glycogen_syn; Glycogen synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCB3.2 GenPept UniProtKB/Swiss-Prot:Q8VCB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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