Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp26b1provided by MGI
Official Full Name: cytochrome P450, family 26, subfamily b, polypeptide 1provided by MGI
Primary source: MGI:MGI:2176159
See related: Ensembl:ENSMUSG00000063415 AllianceGenome:MGI:2176159
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CP26; P450RAI-2
Summary: Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; and retinoic acid binding activity. Involved in positive regulation of gene expression; positive regulation of tongue muscle cell differentiation; and tongue morphogenesis. Acts upstream of or within several processes, including cellular response to retinoic acid; male gamete generation; and skin development. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 5.4), limb E14.5 (RPKM 4.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 36.45 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (84548396..84570890, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (84571414..84593908, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial Cyp26b1 restrains murine heart valve growth during development.
Title: Endothelial Cyp26b1 restrains murine heart valve growth during development.
Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
Title: Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.
CYP26B1 declines postnatally in Sertoli cells independently of androgen action in the mouse testis.
Title: CYP26B1 declines postnatally in Sertoli cells independently of androgen action in the mouse testis.
defects observed in Cyp26b1(-/-) lungs are caused by both RA-dependent and RA-independent mechanisms
Title: Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development.
Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation.
Title: Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation.
Cyp26b1 expression in the vestibular organs during embryogenesis.Formation of the striolar/central zone requires Cyp26b1 -mediated degradation of retinoic acid.
Title: Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.
This study concluded that retinoic acid and STRA8 are conserved factors that control the initiation of meiosis amongst mammals but the role of CYP26B1 as a meiosis-inhibiting factor may be specific to rodents.
Title: Expression of STRA8 is conserved in therian mammals but expression of CYP26B1 differs between marsupials and mice.
elimination of CYP26B1 activity within both germ and Sertoli cells resulted in severe male subfertility, with a loss of advanced germ cells from the seminiferous epithelium.
Title: CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis.
The results of this study concluded that stimulus-dependent neuronal activity can control the expression of the RA catabolic enzyme Cyp26B1 and downstream genes such as BACE1.
Title: Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.
The study showed that a stimulus-dependent gradient of a retinoic acid-inactivating enzyme Cyp26B1 modifies the composition, localization
Title: The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

UniSTS:464663 (e-PCR)
- UniSTS:464663

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:464663

BF398420 (e-PCR)
- UniSTS:246808

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:508549

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:525748

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:506831

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:547815

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:256999

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:519408

D4Got92 (e-PCR)
- UniSTS:115447

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cornification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of skin barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tongue muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid catabolic process	IC Inferred by Curator more info	PubMed
involved_in retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid metabolic process	IC Inferred by Curator more info	PubMed
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tongue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 26B1

Names: cytochrome P450 retinoic acid-inactivating 2; cytochrome P450, 26, retinoic acid B1; cytochrome P450RAI-2; retinoic acid B1; retinoic acid hydroxylase

NP_001171184.1

EC 1.14.13.-

NP_780684.1

EC 1.14.13.-

XP_006506035.1

EC 1.14.13.-

XP_011239602.1

EC 1.14.13.-

XP_030111198.1

EC 1.14.13.-

XP_036021940.1

EC 1.14.13.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177713.1 → NP_001171184.1 cytochrome P450 26B1

See identical proteins and their annotated locations for NP_001171184.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC153606, BC059246

Consensus CDS

CCDS20289.1

UniProtKB/Swiss-Prot

Q3TM12, Q811W2

UniProtKB/TrEMBL

A0A0N4SV88

Related

ENSMUSP00000128391.3, ENSMUST00000168003.9

Conserved Domains (1) summary

cd20637
Location:60 → 490

CYP26B1; cytochrome P450 family 26, subfamily B, polypeptide 1
NM_175475.3 → NP_780684.1 cytochrome P450 26B1

See identical proteins and their annotated locations for NP_780684.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC153606, AY134662

Consensus CDS

CCDS20289.1

UniProtKB/Swiss-Prot

Q3TM12, Q811W2

UniProtKB/TrEMBL

A0A0N4SV88

Related

ENSMUSP00000076886.4, ENSMUST00000077705.6

Conserved Domains (1) summary

cd20637
Location:60 → 490

CYP26B1; cytochrome P450 family 26, subfamily B, polypeptide 1