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Pabpc4 poly(A) binding protein, cytoplasmic 4 [ Mus musculus (house mouse) ]

Gene ID: 230721, updated on 5-Mar-2024

Summary

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Official Symbol
Pabpc4provided by MGI
Official Full Name
poly(A) binding protein, cytoplasmic 4provided by MGI
Primary source
MGI:MGI:2385206
See related
Ensembl:ENSMUSG00000011257 AllianceGenome:MGI:2385206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables mRNA binding activity. Acts upstream of or within myeloid cell development and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in central nervous system; sensory organ; and tooth. Orthologous to human PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 71.8), liver E14.5 (RPKM 71.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pabpc4 in Genome Data Viewer
Location:
4 D2.2; 4 57.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123172722..123192718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123282303..123298925)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:122960063-122960364 Neighboring gene predicted gene, 50623 Neighboring gene predicted gene 12900 Neighboring gene STARR-positive B cell enhancer ABC_E2118 Neighboring gene predicted gene, 25788 Neighboring gene predicted gene, 22154 Neighboring gene STARR-seq mESC enhancer starr_11290 Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene predicted gene 12924

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. Oliveira AG, et al. J Biol Chem, 2023 Jun. PMID 37059182, Free PMC Article
  2. Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Kini HK, et al. Mol Cell Biol, 2014 Apr. PMID 24469397, Free PMC Article
  3. Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. Burgess HM, et al. J Cell Sci, 2011 Oct 1. PMID 21940797, Free PMC Article
  4. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Onishi M, et al. Genomics, 2004 Apr. PMID 15028287
  5. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.
    Title: Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.
  2. selective depletion of PABPC4 in an erythroblast cell line inhibits terminal erythroid maturation with corresponding alterations in the erythroid gene expression
    Title: Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC6685, MGC11665

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables poly(C) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within myeloid cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356377.1 → NP_001343306.1  polyadenylate-binding protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606917, BC056432
    UniProtKB/TrEMBL
    Q99LF8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 611
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  2. NM_130881.3 → NP_570951.2  polyadenylate-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_570951.2

    Status: VALIDATED

    Source sequence(s)
    AL606917, BC056432
    Consensus CDS
    CCDS18614.1
    UniProtKB/TrEMBL
    Q6PHQ9, Q99LF8
    Related
    ENSMUSP00000079070.7, ENSMUST00000080178.13
    Conserved Domains (6) summary
    TIGR01628
    Location:11 → 640
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:12 → 91
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:97 → 172
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:190 → 269
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:293 → 370
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:572 → 639
    PABP; Poly-adenylate binding protein, unique domain

  3. NM_148917.3 → NP_683717.1  polyadenylate-binding protein 4 isoform 2

    See identical proteins and their annotated locations for NP_683717.1

    Status: VALIDATED

    Source sequence(s)
    AL606917, BC056432
    Consensus CDS
    CCDS18615.1
    UniProtKB/TrEMBL
    Q91YZ8, Q99LF8
    Related
    ENSMUSP00000077794.6, ENSMUST00000078734.12
    Conserved Domains (6) summary
    TIGR01628
    Location:11 → 595
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:12 → 91
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:97 → 172
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:190 → 269
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:293 → 370
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:527 → 594
    PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123172722..123192718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503023.4 → XP_006503086.1  polyadenylate-binding protein 4 isoform X6

    Conserved Domains (1) summary
    TIGR01628
    Location:1 → 418
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  2. XM_030253447.2 → XP_030109307.1  polyadenylate-binding protein 4 isoform X9

    Conserved Domains (1) summary
    TIGR01628
    Location:1 → 389
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  3. XM_006503024.4 → XP_006503087.1  polyadenylate-binding protein 4 isoform X7

    Conserved Domains (1) summary
    TIGR01628
    Location:1 → 402
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  4. XM_036164042.1 → XP_036019935.1  polyadenylate-binding protein 4 isoform X10

    Conserved Domains (1) summary
    TIGR01628
    Location:1 → 373
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  5. XM_006503020.4 → XP_006503083.1  polyadenylate-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    Q99LF8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 640
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  6. XM_006503022.4 → XP_006503085.1  polyadenylate-binding protein 4 isoform X4

    UniProtKB/TrEMBL
    A3KFU5, Q99LF8
    Related
    ENSMUSP00000101850.2, ENSMUST00000106243.8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 611
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  7. XM_006503021.4 → XP_006503084.1  polyadenylate-binding protein 4 isoform X2

    UniProtKB/TrEMBL
    A3KFU8, Q99LF8
    Related
    ENSMUSP00000101848.2, ENSMUST00000106241.8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 624
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  8. XM_030253445.2 → XP_030109305.1  polyadenylate-binding protein 4 isoform X5

    UniProtKB/TrEMBL
    Q99LF8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 595
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  9. XM_036164041.1 → XP_036019934.1  polyadenylate-binding protein 4 isoform X8

    Conserved Domains (1) summary
    TIGR01628
    Location:1 → 402
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  10. XM_030253444.2 → XP_030109304.1  polyadenylate-binding protein 4 isoform X3

    UniProtKB/TrEMBL
    Q99LF8
    Conserved Domains (1) summary
    TIGR01628
    Location:11 → 624
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
Nucleotide Protein Strain
Heading Accession and Version

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