Nt5c1a 5'-nucleotidase, cytosolic IA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nt5c1aprovided by MGI
Official Full Name: 5'-nucleotidase, cytosolic IAprovided by MGI
Primary source: MGI:MGI:2155700
See related: Ensembl:ENSMUSG00000054958 AllianceGenome:MGI:2155700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cn1a; Gm49
Summary: Predicted to enable IMP 5'-nucleotidase activity. Acts upstream of or within purine nucleoside monophosphate catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in cranium; integumental system; limb; and nervous system. Orthologous to human NT5C1A (5'-nucleotidase, cytosolic IA). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 8.9), adrenal adult (RPKM 7.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.4 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123095026..123119128)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123201230..123225339)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.
Title: Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.
NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle
Title: Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Nt5c1a (e-PCR), detects polymorphism
- UniSTS:546903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables IMP 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in IMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in adenosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dAMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleoside monophosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cytosolic 5'-nucleotidase 1A

Names: 5'-deoxynucleotidase; cN-IA; cytosolic 5' nucleotidase, type 1A; cytosolic 5'-nucleotidase IA

NP_001078971.1

EC 3.1.3.5

EC 3.1.3.89

EC 3.1.3.99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.