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Tesk2 testis-specific kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 230661, updated on 5-Mar-2024

Summary

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Official Symbol
Tesk2provided by MGI
Official Full Name
testis-specific kinase 2provided by MGI
Primary source
MGI:MGI:2385204
See related
Ensembl:ENSMUSG00000033985 AllianceGenome:MGI:2385204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actin cytoskeleton organization; focal adhesion assembly; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.8), large intestine adult (RPKM 7.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.3 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116578107..116661450)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116720909..116804248)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AV051173 Neighboring gene peroxiredoxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9593 Neighboring gene STARR-positive B cell enhancer ABC_E2706 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene STARR-positive B cell enhancer ABC_E37 Neighboring gene STARR-seq mESC enhancer starr_11147 Neighboring gene STARR-seq mESC enhancer starr_11148 Neighboring gene STARR-seq mESC enhancer starr_11149 Neighboring gene STARR-positive B cell enhancers ABC_E11715 and ABC_E10249 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116480418-116480527 Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC29168

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity testis-specific protein kinase 2
Names
testicular protein kinase 2
NP_666263.3
XP_006503071.1
XP_030109303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146151.4 → NP_666263.3  dual specificity testis-specific protein kinase 2

    See identical proteins and their annotated locations for NP_666263.3

    Status: VALIDATED

    Source sequence(s)
    AK047755, AL683847
    Consensus CDS
    CCDS18516.1
    UniProtKB/Swiss-Prot
    Q8VCT9
    UniProtKB/TrEMBL
    Q8C0B6
    Related
    ENSMUSP00000041009.7, ENSMUST00000045542.13
    Conserved Domains (2) summary
    smart00219
    Location:62 → 309
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64 → 316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116578107..116661450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253443.2 → XP_030109303.1  dual specificity testis-specific protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q8C0B6
    Conserved Domains (1) summary
    cd14155
    Location:144 → 396
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

  2. XM_006503008.5 → XP_006503071.1  dual specificity testis-specific protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 200
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCT9.1 GenPept UniProtKB/Swiss-Prot:Q8VCT9

Gene LinkOut

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