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Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 229709, updated on 11-Apr-2024

Summary

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Official Symbol
Ahcyl1provided by MGI
Official Full Name
S-adenosylhomocysteine hydrolase-like 1provided by MGI
Primary source
MGI:MGI:2385184
See related
Ensembl:ENSMUSG00000027893 AllianceGenome:MGI:2385184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCAL; Irbit; Ahcy-rs3; 1110034F20Rik
Summary
Predicted to enable identical protein binding activity. Involved in epithelial fluid transport. Acts upstream of or within several processes, including mRNA polyadenylation; protein export from nucleus; and regulation of ion transport. Located in cytosol and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 80.6), cortex adult (RPKM 64.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ahcyl1 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107570436..107603876, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107663120..107696560, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene striatin interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107434637-107434746 Neighboring gene predicted gene 10961 Neighboring gene predicted gene, 52629 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107499306-107499489 Neighboring gene predicted gene, 40121 Neighboring gene STARR-seq mESC enhancer starr_08670 Neighboring gene colony stimulating factor 1 (macrophage) Neighboring gene uncharacterized LOC118568636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP(3) (IRBIT). Goto JI, et al. Learn Mem, 2022 Apr. PMID 35351819, Free PMC Article
  2. F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis. Martins JR, et al. Biochim Biophys Acta, 2011 Nov. PMID 21907281
  3. IRBIT: it is everywhere. Yang D, et al. Neurochem Res, 2011 Jul. PMID 21152975, Free PMC Article
  4. Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney. Gomi T, et al. Biochim Biophys Acta, 2008 Nov. PMID 18804558
  5. The IRBIT domain adds new functions to the AHCY family. Devogelaere B, et al. Bioessays, 2008 Jul. PMID 18536033

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP3 (IRBIT).
    Title: Synaptic plasticity in hippocampal CA1 neurons of mice lacking inositol-1,4,5-trisphosphate receptor-binding protein released with IP(3) (IRBIT).
  2. Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO3(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.
    Title: Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(-)/HCO(3)(-) exchanger AE2 activity through modulating the lysosomal degradation of AE2.
  3. IRBIT controlled five phosphorylation sites in NBCe1-B that determined both the active conformation of the transporter and its regulation by Cl(-)
    Title: Modulation of Cl(-) signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT.
  4. NHERF1 mediates ANG II-induced activation of renal NHE3, which requires coordination between IRBIT and the NHERF1 PDZ1 domain in binding and transporting NHE3
    Title: The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.
  5. IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.
    Title: IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.
  6. IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation.
    Title: IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.
  7. Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum
    Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.
  8. IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities
    Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
  9. Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 and by inhibiting PAP activity, in response to a stimulus that alters its phosphorylation state.
    Title: Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.
  10. Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion.
    Title: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables adenosylhomocysteinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of monoatomic anion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-adenosylhomocysteine hydrolase-like protein 1
Names
IP3R binding protein released with inositol 1,4,5-trisphosphate
S-adenosyl-L-homocysteine hydrolase 2
S-adenosylhomocysteine hydrolase, related sequence 3
adoHcyase 2
putative adenosylhomocysteinase 2
NP_001344039.1
NP_001344040.1
NP_001344041.1
NP_001344042.1
NP_663517.2
XP_030108450.1
XP_030108451.1
XP_030108452.1
XP_030108453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357110.1 → NP_001344039.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    UniProtKB/TrEMBL
    Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:59 → 482
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  2. NM_001357111.1 → NP_001344040.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:2 → 312
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001357112.1 → NP_001344041.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:2 → 312
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_001357113.1 → NP_001344042.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122902, AC140786, BQ176498
    Conserved Domains (1) summary
    cl21454
    Location:21 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_145542.4 → NP_663517.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_663517.2

    Status: VALIDATED

    Source sequence(s)
    AB092504, AC122902, AC140786, AK004088, BQ176498, CJ162898
    Consensus CDS
    CCDS38593.1
    UniProtKB/Swiss-Prot
    Q80SW1
    UniProtKB/TrEMBL
    Q80TQ9
    Related
    ENSMUSP00000029490.9, ENSMUST00000029490.15
    Conserved Domains (1) summary
    smart00996
    Location:106 → 529
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107570436..107603876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252590.2 → XP_030108450.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_030252592.2 → XP_030108452.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_030252593.2 → XP_030108453.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:21 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_030252591.2 → XP_030108451.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:21 → 288
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SW1.1 GenPept UniProtKB/Swiss-Prot:Q80SW1

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