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Atp5mc3 ATP synthase membrane subunit c locus 3 [ Mus musculus (house mouse) ]

Gene ID: 228033, updated on 11-Apr-2024

Summary

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Official Symbol
Atp5mc3provided by MGI
Official Full Name
ATP synthase membrane subunit c locus 3provided by MGI
Primary source
MGI:MGI:2442035
See related
Ensembl:ENSMUSG00000018770 AllianceGenome:MGI:2442035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5g3; 6030447M23
Summary
The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in heart adult (RPKM 896.5), kidney adult (RPKM 502.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Atp5mc3 in Genome Data Viewer
Location:
2 C3; 2 43.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73738791..73742793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73908447..73912464, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene STARR-seq mESC enhancer starr_04840 Neighboring gene STARR-seq mESC enhancer starr_04842 Neighboring gene activating transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_04843 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73705882-73706183 Neighboring gene STARR-positive B cell enhancer ABC_E809 Neighboring gene STARR-positive B cell enhancer ABC_E4468 Neighboring gene predicted gene 10822 Neighboring gene predicted gene, 39851 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective. Huang Y, et al. Genet Mol Res, 2013 Sep 18. PMID 24085430, Free PMC Article
  2. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
  3. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
  4. Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Hupe M, et al. Nucleic Acids Res, 2014 Jan. PMID 24165879, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes.
    Title: Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124584

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligand-gated channel activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cation channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase F(0) complex subunit C3, mitochondrial
Names
ATP synthase lipid-binding protein, mitochondrial
ATP synthase proteolipid P3
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
ATPase protein 9
ATPase subunit c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301721.1 → NP_001288650.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001288650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI851824, AL844581, CF104340, CX208968
    Consensus CDS
    CCDS16136.1
    UniProtKB/Swiss-Prot
    P56384
    UniProtKB/TrEMBL
    Q14BC2
    Related
    ENSMUSP00000107627.2, ENSMUST00000111996.8
    Conserved Domains (1) summary
    MTH00222
    Location:67 → 141
    ATP9; ATP synthase F0 subunit 9; Provisional

  2. NM_001301722.1 → NP_001288651.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001288651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI851824, AL844581, AW554443, CF104340
    Conserved Domains (1) summary
    cl00466
    Location:67 → 89
    ATP-synt_C; ATP synthase subunit C

  3. NM_175015.3 → NP_778180.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_778180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI851824, AL844581, CF104340
    Consensus CDS
    CCDS16136.1
    UniProtKB/Swiss-Prot
    P56384
    UniProtKB/TrEMBL
    Q14BC2
    Related
    ENSMUSP00000018914.3, ENSMUST00000018914.3
    Conserved Domains (1) summary
    MTH00222
    Location:67 → 141
    ATP9; ATP synthase F0 subunit 9; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73738791..73742793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250178.2 → XP_030106038.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P56384
    UniProtKB/TrEMBL
    Q14BC2
    Conserved Domains (1) summary
    MTH00222
    Location:67 → 141
    ATP9; ATP synthase F0 subunit 9; Provisional

  2. XM_030250179.2 → XP_030106039.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00466
    Location:67 → 104
    ATP-synt_C; ATP synthase subunit C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56384.1 GenPept UniProtKB/Swiss-Prot:P56384

Gene LinkOut

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