VEGFD vascular endothelial growth factor D [Homo sapiens (human)] - Gene

Summary

Official Symbol: VEGFDprovided by HGNC
Official Full Name: vascular endothelial growth factor Dprovided by HGNC
Primary source: HGNC:HGNC:3708
See related: Ensembl:ENSG00000165197 MIM:300091; AllianceGenome:HGNC:3708
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIGF; VEGF-D
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
Expression: Biased expression in lung (RPKM 21.7), fat (RPKM 4.7) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp22.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (15345596..15384413, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (14928484..14967347, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (15363718..15402535, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
Title: S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly patients with cardiovascular disease.
Title: Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly patients with cardiovascular disease.
Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors.
Title: Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors.
Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease.
Title: Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease.
Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease.
Title: Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease.
VEGF-D-mediated signaling in tendon cells is involved in degenerative processes.
Title: VEGF-D-mediated signaling in tendon cells is involved in degenerative processes.
circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFbetaR1/VEGF-D signaling.
Title: circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling.
Methacholine reactivity in lymphangioleiomyomatosis is inversely related to FEV1 and VEGF-D.
Title: Methacholine reactivity in lymphangioleiomyomatosis is inversely related to FEV(1) and VEGF-D.
Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients.
Title: Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients.
A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.
Title: A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S1556 (e-PCR)
- UniSTS:153669

STS-Z40756 (e-PCR)
- UniSTS:78176

STS-T64149 (e-PCR)
- UniSTS:64912

RH91522 (e-PCR)
- UniSTS:90792

RH103380 (e-PCR)
- UniSTS:97707

SHGC-34929 (e-PCR)
- UniSTS:46252

STS-H69335 (e-PCR)
- UniSTS:15803

FIGF_1558 (e-PCR)
- UniSTS:277240

FIGF_v539 (e-PCR)
- UniSTS:277240

Readthrough PIR-FIGF

Readthrough gene: PIR-FIGF, Included gene: PIR

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: vascular endothelial growth factor D

Names: c-fos induced growth factor (vascular endothelial growth factor D)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012509.1 RefSeqGene

Range

5043..43860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004469.5 → NP_004460.1 vascular endothelial growth factor D preproprotein

See identical proteins and their annotated locations for NP_004460.1

Status: REVIEWED

Source sequence(s)

BC027948, DA587496

Consensus CDS

CCDS14166.1

UniProtKB/Swiss-Prot

B2R7Z3, O43915

UniProtKB/TrEMBL

Q53FX1

Related

ENSP00000297904.3, ENST00000297904.4

Conserved Domains (1) summary

smart00141
Location:109 → 193

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family