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FGR FGR proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2268, updated on 4-Jan-2025

Summary

Official Symbol
FGRprovided by HGNC
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3697
See related
Ensembl:ENSG00000000938 MIM:164940; AllianceGenome:HGNC:3697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr
Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues See more
Orthologs
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Genomic context

See FGR in Genome Data Viewer
Location:
1p35.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27612064..27635185, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27453366..27476486, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27938575..27961696, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27849319-27849901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27851813-27852451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27855359-27856073 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27864051-27864652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27869009-27869527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27869528-27870045 Neighboring gene AT-hook DNA binding motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27881926-27882481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27889385-27890112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27907956-27908485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27918399-27918972 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27919547-27920120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27920121-27920694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27922307-27922832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27922833-27923358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27924447-27925402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27925403-27926360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27926361-27927316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27928027-27928623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 524 Neighboring gene Sharpr-MPRA regulatory region 12291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27939571-27940071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27941009-27941556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27950023-27950844 Neighboring gene Sharpr-MPRA regulatory region 6936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27958413-27958913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 565 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27977663-27978629 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27981022-27981424 Neighboring gene uncharacterized LOC729973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27985747-27986247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27988849-27989364 Neighboring gene long intergenic non-protein coding RNA 2574

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) in human B cells PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ43153, MGC75096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables Fc-gamma receptor I complex binding PubMed 
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables immunoglobulin receptor binding  
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity PubMed 
enables non-membrane spanning protein tyrosine kinase activity  
enables phosphotyrosine residue binding PubMed 
enables phosphotyrosine residue binding  
enables protein binding PubMed 
enables protein kinase binding  
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity  
enables signaling receptor binding  
Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis  
involved_in bone mineralization  
involved_in cell differentiation  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in chromatin remodeling  
involved_in defense response to Gram-positive bacterium  
involved_in immune response-regulating cell surface receptor signaling pathway PubMed 
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway PubMed 
involved_in integrin-mediated signaling pathway  
involved_in myoblast proliferation  
involved_in negative regulation of inflammatory response to antigenic stimulus  
involved_in negative regulation of natural killer cell activation  
involved_in peptidyl-tyrosine phosphorylation PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of cytokine production  
involved_in positive regulation of mast cell degranulation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in protein autophosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of cell shape  
involved_in regulation of innate immune response  
involved_in regulation of phagocytosis  
involved_in regulation of protein kinase activity  
involved_in response to virus PubMed 
involved_in skeletal system morphogenesis  
Items 1 - 25 of 26
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton  
located_in aggresome  
colocalizes_with cytoskeleton PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in mitochondrial inner membrane  
located_in mitochondrial intermembrane space  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
colocalizes_with ruffle membrane  
located_in secretory granule lumen  

General protein information

Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
c-fgr protooncogene
c-src-2 proto-oncogene
feline Gardner-Rasheed sarcoma viral oncogene homolog
p55-c-fgr protein
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase FGR
v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
NP_001036194.1
NP_001036212.1
NP_005239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042729.2NP_001036194.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates at exon A, resulting in a distinct 5' UTR compared to variant 1. Expression of this variant is upregulated by Epstein-Barr virus. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA960178, M27454
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000363115.3, ENST00000374003.7
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001042747.2NP_001036212.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates at exon M3, resulting in a distinct 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BI771758, BQ448283, BX495937, DA952771
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000382126.1, ENST00000399173.5
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  3. NM_005248.3NP_005239.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_005239.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates at exon M4 and represents the longest transcript. It is expressed in myelomonocytic cells. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA139476
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000363117.3, ENST00000374005.8
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    27612064..27635185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27453366..27476486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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