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Sf1 splicing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 22668, updated on 3-Apr-2024

Summary

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Official Symbol
Sf1provided by MGI
Official Full Name
splicing factor 1provided by MGI
Primary source
MGI:MGI:1095403
See related
Ensembl:ENSMUSG00000024949 AllianceGenome:MGI:1095403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BBP; MZFM; WBP4; Zfp162
Summary
Enables RNA binding activity. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and nuclear body organization. Located in nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human SF1 (splicing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: SF1 (Gene ID: 22668) and NR5A1 (Gene ID: 26423) share the SF1 symbol/alias in common. SF1 is a widely used alternative name for nuclear receptor subfamily 5 group A member 1 (NR5A1), which can be confused with the official symbol for SF1 (splicing factor 1). [30 Mar 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 49.7), adrenal adult (RPKM 41.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6413952..6428060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6363673..6378038)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene predicted gene, 57665 Neighboring gene muscle glycogen phosphorylase Neighboring gene STARR-positive B cell enhancer ABC_E4263 Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Shitashige M, et al. Cancer Sci, 2007 Dec. PMID 17900258
  2. Genomic organization of mouse gene zfp162. Wrehlke C, et al. DNA Cell Biol, 1999 May. PMID 10360842
  3. Enhanced expression in spleen macrophages of the mouse homolog to the human putative tumor suppressor gene ZFM1. Wrehlke C, et al. DNA Cell Biol, 1997 Jun. PMID 9212169
  4. Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors. Qin F, et al. Reprod Biomed Online, 2015 Nov. PMID 26386639
  5. SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells. Kulcenty K, et al. Mol Cell Biochem, 2015 Oct. PMID 26122391, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sf1 SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone)
    Title: Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
  2. we found that KLF6 transcriptionally cooperates with NUR77 and SF1
    Title: KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.
  3. the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 expression.
    Title: Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors.
  4. Results clearly indicate that SF-1 is involved in the regulation of LIPE expression after activation of protein kinase A in adrenocortical cells.
    Title: SF-1 (NR5A1) expression is stimulated by the PKA pathway and is essential for the PKA-induced activation of LIPE expression in Y-1 cells.
  5. SF-1 is involved in cell cycle regulation, neurogenesis, and neuronal migration via controlling the estrogen signaling for proper neocortical development.
    Title: Involvement of SF-1 in neurogenesis and neuronal migration in the developing neocortex.
  6. SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
    Title: SIRT1 Relays Nutritional Inputs to the Circadian Clock Through the Sf1 Neurons of the Ventromedial Hypothalamus.
  7. Data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis.
    Title: Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.
  8. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis indicates the involvement of SF1 in the beta-catenin-mediated regulation of proliferation.
    Title: Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within male sex determination IGI
Inferred from Genetic Interaction
more info
  
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of steroid biosynthetic process IGI
Inferred from Genetic Interaction
more info
  
Component Evidence Code Pubs
part_of U2AF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
splicing factor 1
Names
mammalian branch point-binding protein
transcription factor ZFM1
zinc finger gene in MEN1 locus
zinc finger protein 162

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110791.2 → NP_001104261.1  splicing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001104261.1

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Consensus CDS
    CCDS50368.1
    UniProtKB/TrEMBL
    Q3UI45, Q3UK67
    Related
    ENSMUSP00000121309.2, ENSMUST00000131252.8
    Conserved Domains (2) summary
    smart00343
    Location:278 → 293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17 → 257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

  2. NM_001360393.2 → NP_001347322.1  splicing factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Conserved Domains (1) summary
    cl25681
    Location:29 → 211
    SF1-HH; Splicing factor 1 helix-hairpin domain

  3. NM_001403434.1 → NP_001390363.1  splicing factor 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  4. NM_001403435.1 → NP_001390364.1  splicing factor 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  5. NM_001403436.1 → NP_001390365.1  splicing factor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  6. NM_001403439.1 → NP_001390368.1  splicing factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  7. NM_001403440.1 → NP_001390369.1  splicing factor 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    UniProtKB/TrEMBL
    D3YZC9
    Related
    ENSMUSP00000109117.2, ENSMUST00000113489.8

  8. NM_001403441.1 → NP_001390370.1  splicing factor 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  9. NM_001403442.1 → NP_001390371.1  splicing factor 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  10. NM_001403443.1 → NP_001390372.1  splicing factor 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  11. NM_001403444.1 → NP_001390373.1  splicing factor 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  12. NM_001403445.1 → NP_001390374.1  splicing factor 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Conserved Domains (2) summary
    smart00343
    Location:278 → 293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17 → 257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

  13. NM_001403446.1 → NP_001390375.1  splicing factor 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  14. NM_001403447.1 → NP_001390376.1  splicing factor 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  15. NM_001403448.1 → NP_001390377.1  splicing factor 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245

  16. NM_001403449.1 → NP_001390378.1  splicing factor 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    UniProtKB/TrEMBL
    D3YZD0
    Related
    ENSMUSP00000109116.2, ENSMUST00000113488.8

  17. NM_011750.3 → NP_035880.2  splicing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_035880.2

    Status: VALIDATED

    Source sequence(s)
    AC127556, AC167245
    Consensus CDS
    CCDS50369.1
    UniProtKB/TrEMBL
    E9Q4Q2, Q3TZI3
    Related
    ENSMUSP00000109115.2, ENSMUST00000113487.8
    Conserved Domains (2) summary
    smart00343
    Location:278 → 293
    ZnF_C2HC; zinc finger
    COG5176
    Location:17 → 257
    MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6413952..6428060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_122118.1: Suppressed sequence

    Description
    NR_122118.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64213.6 GenPept UniProtKB/Swiss-Prot:Q64213

Gene LinkOut

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