Lamc1 laminin, gamma 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamc1provided by MGI
Official Full Name: laminin, gamma 1provided by MGI
Primary source: MGI:MGI:99914
See related: Ensembl:ENSMUSG00000026478 AllianceGenome:MGI:99914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lamb2
Summary: Enables glycosphingolipid binding activity. Acts upstream of or within neuron projection development. Located in basement membrane and synaptic cleft. Part of laminin-10 complex. Is active in neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 50.7), bladder adult (RPKM 46.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 65.3 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (153094668..153208532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (153218922..153332786, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Laminin is the ECM niche for trophoblast stem cells.
Title: Laminin is the ECM niche for trophoblast stem cells.
The Adult Murine Intestine is Dependent on Constitutive Laminin-gamma1 Synthesis.
Title: The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis.
netrin-4 disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain.
Title: Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
epidermal laminin-511 is also a key regulator for later hair development and hair shaft differentiation.
Title: Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP, Lamc1, peroxidasin) during uterine reprogramming.
Title: Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
Title: Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.
Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes.
Title: Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.
The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation.
Title: Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution.
These findings document a pathogenic potential of antibodies targeting the laminin gamma1 N-terminus.
Title: Ex vivo pathogenicity of anti-laminin γ1 autoantibodies.
LNgamma1-knockout mice present with intracerebral hemorrhage in adulthood.
Title: Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit43 (e-PCR), detects polymorphism
- UniSTS:128798

J02930 (e-PCR)
- UniSTS:178479

Lamc1 (e-PCR), detects polymorphism
- UniSTS:256621

Lamc1 (e-PCR), detects polymorphism
- UniSTS:507014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of basement membrane organization	NAS Non-traceable Author Statement more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	NAS Non-traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
part_of laminin-1 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-10 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
part_of protein complex involved in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin subunit gamma-1

Names: S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-1 subunit gamma; laminin-10 subunit gamma; laminin-11 subunit gamma; laminin-2 subunit gamma; laminin-3 subunit gamma; laminin-4 subunit gamma; laminin-6 subunit gamma; laminin-7 subunit gamma; laminin-8 subunit gamma; laminin-9 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010683.2 → NP_034813.2 laminin subunit gamma-1 precursor

See identical proteins and their annotated locations for NP_034813.2

Status: VALIDATED

Source sequence(s)

AC117550, AC159966

Consensus CDS

CCDS15370.1

UniProtKB/Swiss-Prot

P02468

UniProtKB/TrEMBL

F8VQJ3

Related

ENSMUSP00000027752.9, ENSMUST00000027752.15

Conserved Domains (11) summary

cl14654
Location:1178 → 1310

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

smart00136
Location:42 → 282

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:933 → 978

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:551 → 676

LamB; Laminin B domain

smart00283
Location:1089 → 1300

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)

cd00055
Location:980 → 1027

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:443 → 490

Laminin_EGF; Laminin EGF domain

pfam05276
Location:1359 → 1585

SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

pfam17002
Location:1198 → 1403

DUF5089; Domain of unknown function (DUF5089)

cl02488
Location:1047 → 1252

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl21478
Location:1391 → 1503

ATP-synt_B; ATP synthase B/B' CF(0)