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Mapk4 mitogen-activated protein kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 225724, updated on 11-Apr-2024

Summary

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Official Symbol
Mapk4provided by MGI
Official Full Name
mitogen-activated protein kinase 4provided by MGI
Primary source
MGI:MGI:2444559
See related
Ensembl:ENSMUSG00000024558 AllianceGenome:MGI:2444559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erk3; Prkm4; p63Mapk; A330097D03Rik
Summary
Enables protein heterodimerization activity; protein homodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Located in cytoplasm and nucleus. Is expressed in female associated reproductive structure; ureteric tip; and ureteric trunk. Orthologous to human MAPK4 (mitogen-activated protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Mapk4 in Genome Data Viewer
Location:
18 E2; 18 50.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74061557..74198643, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73928486..74065434, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene maestro Neighboring gene RIKEN cDNA D730045A05 gene Neighboring gene STARR-seq mESC enhancer starr_45000 Neighboring gene STARR-seq mESC enhancer starr_45001 Neighboring gene predicted gene 9925 Neighboring gene STARR-seq mESC enhancer starr_45002 Neighboring gene predicted gene, 32801 Neighboring gene predicted gene, 57658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, et al. Genes Dev, 2020 Apr 1. PMID 32139423, Free PMC Article
  2. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Marquis M, et al. Mol Cell Biol, 2014 Sep 15. PMID 25002529, Free PMC Article
  3. The non-classical MAP kinase ERK3 controls T cell activation. Marquis M, et al. PLoS One, 2014. PMID 24475167, Free PMC Article
  4. ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. Li S, et al. PLoS One, 2010 Sep 29. PMID 20927325, Free PMC Article
  5. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. García JI, et al. Mamm Genome, 1996 Nov. PMID 8875888

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C/EBPalpha/miR-7 Controls CD4(+) T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice.
    Title: C/EBPα/miR-7 Controls CD4(+) T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice.
  2. targeted deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation, promoting lean phenotype and ameliorating diabetes
    Title: The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation.
  3. Results uncover a unique role for ERK3, dependent on its kinase activity, during T cell development and show that this atypical MAPK is essential to sustain CD4(+) CD8(+) (DP) thymocytes survival during RAG-mediated rearrangements.
    Title: The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.
  4. The atypical MAPK ERK3 is a new and important regulator of T cell receptor-induced T cell activation.
    Title: The non-classical MAP kinase ERK3 controls T cell activation.
  5. Data suggest that ERK3 is crucial for spindle stability and required for the metaphase-anaphase transition in mouse oocyte maturation.
    Title: ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis.
  6. Data suggest that Erk4 is dispensable for mouse embryonic development and reveals that Erk3 and Erk4 have acquired specialized functions through evolutionary diversification.
    Title: Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.
  7. a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse
    Title: Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.
  8. Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.
    Title: Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 4
Names
ERK-4
Erk3-related
MAP kinase 4
MAPK 4
extracellular signal-regulated kinase 4
NP_001347865.1
NP_766220.2
XP_006525963.1
XP_006525964.1
XP_030106306.1
XP_030106307.1
XP_030106308.1
XP_036017016.1
XP_036017017.1
XP_036017018.1
XP_036017019.1
XP_036017020.1
XP_036017021.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360936.1 → NP_001347865.1  mitogen-activated protein kinase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124367
    Conserved Domains (1) summary
    cl21453
    Location:2 → 172
    PKc_like; Protein Kinases, catalytic domain

  2. NM_172632.2 → NP_766220.2  mitogen-activated protein kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_766220.2

    Status: VALIDATED

    Source sequence(s)
    BC058942, BC094564, CB526503
    Consensus CDS
    CCDS37856.1
    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Related
    ENSMUSP00000089462.4, ENSMUST00000091851.10
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    74061557..74198643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525901.5 → XP_006525964.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_006525964.1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  2. XM_036161128.1 → XP_036017021.1  mitogen-activated protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 114
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036161125.1 → XP_036017018.1  mitogen-activated protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 114
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036161123.1 → XP_036017016.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  5. XM_030250447.2 → XP_030106307.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  6. XM_036161124.1 → XP_036017017.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  7. XM_030250448.1 → XP_030106308.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 140
    PKc_like; Protein Kinases, catalytic domain

  8. XM_006525900.4 → XP_006525963.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_006525963.1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  9. XM_036161126.1 → XP_036017019.1  mitogen-activated protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 114
    PKc_like; Protein Kinases, catalytic domain

  10. XM_030250446.2 → XP_030106306.1  mitogen-activated protein kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P5G0
    UniProtKB/TrEMBL
    Q8BV72
    Conserved Domains (1) summary
    cd07854
    Location:14 → 351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)

  11. XM_036161127.1 → XP_036017020.1  mitogen-activated protein kinase 4 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 114
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5G0.1 GenPept UniProtKB/Swiss-Prot:Q6P5G0

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