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Tfb1m transcription factor B1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 224481, updated on 4-Jan-2025

Summary

Official Symbol
Tfb1mprovided by MGI
Official Full Name
transcription factor B1, mitochondrialprovided by MGI
Primary source
MGI:MGI:2146851
See related
Ensembl:ENSMUSG00000036983 AllianceGenome:MGI:2146851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mtTFB1
Summary
Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Involved in rRNA methylation. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer; early conceptus; heart; secondary oocyte; and tibialis anterior. Orthologous to human TFB1M (transcription factor B1, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 12.7), liver E14 (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See Tfb1m in Genome Data Viewer
Location:
17 A1; 17 2.01 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (3569119..3608064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (3519250..3557796, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene T cell lymphoma invasion and metastasis 2 Neighboring gene STARR-seq mESC enhancer starr_41658 Neighboring gene predicted gene, 52295 Neighboring gene STARR-positive B cell enhancer mm9_chr17:3451087-3451388 Neighboring gene ribosomal protein L18A pseudogene Neighboring gene STARR-seq mESC enhancer starr_41660 Neighboring gene claudin 20 Neighboring gene RIKEN cDNA 1700102H20 gene Neighboring gene STARR-positive B cell enhancer ABC_E5570 Neighboring gene predicted gene, 34155

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

General gene information

Clone Names

  • MGC41387

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in rRNA methylation  
involved_in rRNA methylation PubMed 
involved_in rRNA methylation  
involved_in rRNA methylation  
involved_in transcription initiation at mitochondrial promoter  
Component Evidence Code Pubs
is_active_in mitochondrial matrix  
located_in mitochondrial nucleoid  
located_in mitochondrial nucleoid  
located_in mitochondrion PubMed 

General protein information

Preferred Names
dimethyladenosine transferase 1, mitochondrial
Names
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1
mitochondrial 12S rRNA dimethylase 1
NP_666186.1
XP_036016402.1
XP_036016403.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146074.3NP_666186.1  dimethyladenosine transferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_666186.1

    Status: VALIDATED

    Source sequence(s)
    AC098838, AC122350
    Consensus CDS
    CCDS28363.1
    UniProtKB/Swiss-Prot
    Q8JZM0
    Related
    ENSMUSP00000035291.7, ENSMUST00000041003.8
    Conserved Domains (1) summary
    PRK00274
    Location:15310
    ksgA; 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    3569119..3608064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160510.1XP_036016403.1  dimethyladenosine transferase 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:6215
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_036160509.1XP_036016402.1  dimethyladenosine transferase 1, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:15222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_385130.4 RNA Sequence

  2. XR_004939510.1 RNA Sequence

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