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FES FES proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2242, updated on 11-Apr-2024

Summary

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Official Symbol
FESprovided by HGNC
Official Full Name
FES proto-oncogene, tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3657
See related
Ensembl:ENSG00000182511 MIM:190030; AllianceGenome:HGNC:3657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPS
Summary
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Expression
Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
15q26.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90884504..90895776)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88643915..88655365)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91427734..91439006)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 363, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:91412350-91413549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10097 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10101 Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10103 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of c-fes gene in leukemia cells and its clinical significance]. Zhang YL, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009 Dec. PMID 20030920
  2. Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. Shaffer JM, et al. Biochemistry, 2009 Jun 9. PMID 19382747, Free PMC Article
  3. Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells. Kanda S, et al. Int J Oncol, 2009 Jan. PMID 19082481, Free PMC Article
  4. Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer. Shaffer JM, et al. Genes Chromosomes Cancer, 2009 Mar. PMID 19051325, Free PMC Article
  5. A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. Delfino FJ, et al. J Biol Chem, 2006 Mar 31. PMID 16455651

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
    Title: The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
  2. Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
    Title: Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
  3. This study supports the critical role of FER and FES tyrosine kinase fusions in the pathogenesis of follicular T-cell lymphoma and provides additional evidence that these can drive follicular T-cell lymphoma in the absence of RHOA mutations.
    Title: FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.
  4. analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells
    Title: A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.
  5. c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias.
    Title: [Expression of c-fes gene in leukemia cells and its clinical significance].
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  7. FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.
    Title: FES kinase participates in KIT-ligand induced chemotaxis.
  8. FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells
    Title: Inhibition of endothelial cell chemotaxis toward FGF-2 by gefitinib associates with downregulation of Fes activity.
  9. c-Fes oligomerization is independent of activation; data suggest that conformational changes, rather than oligomerization, govern c-Fes kinase activation and downstream signaling in vivo.
    Title: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to vitamin D IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
  
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fes/Fps
Names
Oncogene FES, feline sarcoma virus
feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
feline sarcoma oncogene
feline sarcoma/Fujinami avian sarcoma oncogene homolog
p93c-fes
proto-oncogene c-Fes
proto-oncogene c-Fps
proto-oncogene tyrosine-protein kinase Fes/Fps
NP_001137255.1
NP_001137256.1
NP_001137257.1
NP_001996.1
XP_005254937.1
XP_005254939.1
XP_016877494.1
XP_016877495.1
XP_016877496.1
XP_016877497.1
XP_016877498.1
XP_016877499.1
XP_047288189.1
XP_047288190.1
XP_047288191.1
XP_047288192.1
XP_047288193.1
XP_047288194.1
XP_047288195.1
XP_054233470.1
XP_054233471.1
XP_054233472.1
XP_054233473.1
XP_054233474.1
XP_054233475.1
XP_054233476.1
XP_054233477.1
XP_054233478.1
XP_054233479.1
XP_054233480.1
XP_054233481.1
XP_054233482.1
XP_054233483.1
XP_054233484.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029671.1 RefSeqGene

    Range
    5047..16319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143783.1 → NP_001137255.1  tyrosine-protein kinase Fes/Fps isoform 2

    See identical proteins and their annotated locations for NP_001137255.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513656
    Consensus CDS
    CCDS45350.1
    UniProtKB/TrEMBL
    B4DUD9
    Related
    ENSP00000377837.3, ENST00000394300.7
    Conserved Domains (4) summary
    cd10361
    Location:395 → 479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506 → 757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503 → 756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001143784.1 → NP_001137256.1  tyrosine-protein kinase Fes/Fps isoform 3

    See identical proteins and their annotated locations for NP_001137256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513657
    Consensus CDS
    CCDS45349.1
    UniProtKB/TrEMBL
    B4DUD9
    Related
    ENSP00000400868.2, ENST00000444422.2
    Conserved Domains (3) summary
    cd05084
    Location:494 → 745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491 → 744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001143785.2 → NP_001137257.1  tyrosine-protein kinase Fes/Fps isoform 4

    See identical proteins and their annotated locations for NP_001137257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513654, DB264752
    Consensus CDS
    CCDS45351.1
    UniProtKB/TrEMBL
    E7ENM8
    Related
    ENSP00000414629.2, ENST00000414248.6
    Conserved Domains (3) summary
    cd05084
    Location:436 → 687
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:433 → 686
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_002005.4 → NP_001996.1  tyrosine-protein kinase Fes/Fps isoform 1

    See identical proteins and their annotated locations for NP_001996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124248, X52192
    Consensus CDS
    CCDS10365.1
    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
    UniProtKB/TrEMBL
    B4DUD9
    Related
    ENSP00000331504.3, ENST00000328850.8
    Conserved Domains (4) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564 → 815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561 → 814
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90884504..90895776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022009.3 → XP_016877498.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (4) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564 → 815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561 → 814
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_047432235.1 → XP_047288191.1  tyrosine-protein kinase Fes/Fps isoform X3

  3. XM_017022010.2 → XP_016877499.1  tyrosine-protein kinase Fes/Fps isoform X2

    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (4) summary
    cd10361
    Location:395 → 479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506 → 757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503 → 756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_047432237.1 → XP_047288193.1  tyrosine-protein kinase Fes/Fps isoform X4

  5. XM_047432233.1 → XP_047288189.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

  6. XM_047432234.1 → XP_047288190.1  tyrosine-protein kinase Fes/Fps isoform X2

  7. XM_005254882.3 → XP_005254939.1  tyrosine-protein kinase Fes/Fps isoform X3

    See identical proteins and their annotated locations for XP_005254939.1

    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (3) summary
    cd05084
    Location:494 → 745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491 → 744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. XM_005254880.2 → XP_005254937.1  tyrosine-protein kinase Fes/Fps isoform X2

    See identical proteins and their annotated locations for XP_005254937.1

    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (4) summary
    cd10361
    Location:395 → 479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506 → 757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503 → 756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_017022005.2 → XP_016877494.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (4) summary
    cd07685
    Location:7 → 239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453 → 537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564 → 815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561 → 814
    Pkinase_Tyr; Protein tyrosine kinase

  10. XM_017022007.2 → XP_016877496.1  tyrosine-protein kinase Fes/Fps isoform X3

    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (3) summary
    cd05084
    Location:494 → 745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491 → 744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_017022006.2 → XP_016877495.1  tyrosine-protein kinase Fes/Fps isoform X2

    UniProtKB/TrEMBL
    B4DUD9
    Conserved Domains (4) summary
    cd10361
    Location:395 → 479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506 → 757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503 → 756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_017022008.2 → XP_016877497.1  tyrosine-protein kinase Fes/Fps isoform X4

    UniProtKB/TrEMBL
    E7ENM8
    Conserved Domains (3) summary
    cd05084
    Location:436 → 687
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:433 → 686
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  13. XM_047432239.1 → XP_047288195.1  tyrosine-protein kinase Fes/Fps isoform X5

    Related
    ENSP00000435811.1, ENST00000464684.5

  14. XM_047432236.1 → XP_047288192.1  tyrosine-protein kinase Fes/Fps isoform X5

  15. XM_047432238.1 → XP_047288194.1  tyrosine-protein kinase Fes/Fps isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88643915..88655365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377499.1 → XP_054233474.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

  2. XM_054377507.1 → XP_054233482.1  tyrosine-protein kinase Fes/Fps isoform X4

  3. XM_054377505.1 → XP_054233480.1  tyrosine-protein kinase Fes/Fps isoform X3

  4. XM_054377502.1 → XP_054233477.1  tyrosine-protein kinase Fes/Fps isoform X2

  5. XM_054377503.1 → XP_054233478.1  tyrosine-protein kinase Fes/Fps isoform X2

  6. XM_054377500.1 → XP_054233475.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

  7. XM_054377504.1 → XP_054233479.1  tyrosine-protein kinase Fes/Fps isoform X3

  8. XM_054377501.1 → XP_054233476.1  tyrosine-protein kinase Fes/Fps isoform X2

  9. XM_054377495.1 → XP_054233470.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5

  10. XM_054377497.1 → XP_054233472.1  tyrosine-protein kinase Fes/Fps isoform X3

  11. XM_054377496.1 → XP_054233471.1  tyrosine-protein kinase Fes/Fps isoform X2

  12. XM_054377498.1 → XP_054233473.1  tyrosine-protein kinase Fes/Fps isoform X4

  13. XM_054377509.1 → XP_054233484.1  tyrosine-protein kinase Fes/Fps isoform X5

  14. XM_054377506.1 → XP_054233481.1  tyrosine-protein kinase Fes/Fps isoform X5

  15. XM_054377508.1 → XP_054233483.1  tyrosine-protein kinase Fes/Fps isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07332.3 GenPept UniProtKB/Swiss-Prot:P07332

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