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Wnt3a wingless-type MMTV integration site family, member 3A [ Mus musculus (house mouse) ]

Gene ID: 22416, updated on 4-Jan-2025

Summary

Official Symbol
Wnt3aprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 3Aprovided by MGI
Primary source
MGI:MGI:98956
See related
Ensembl:ENSMUSG00000009900 AllianceGenome:MGI:98956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vt; Wnt-3a
Summary
Enables several functions, including identical protein binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including Wnt signaling pathway; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within with a positive effect on positive regulation of type B pancreatic cell proliferation. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and positive regulation of cell population proliferation. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in lung adult (RPKM 5.7), testis adult (RPKM 1.9) and 3 other tissues See more
Orthologs
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Genomic context

See Wnt3a in Genome Data Viewer
Location:
11 B1.3; 11 37.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59138859..59181579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59248036..59290751, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310033P09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3955 Neighboring gene ARF GTPase 1 Neighboring gene STARR-seq mESC enhancer starr_29621 Neighboring gene wingless-type MMTV integration site family, member 9A Neighboring gene predicted gene, 51865 Neighboring gene serine protease 38 Neighboring gene predicted gene 15755

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Spontaneous (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables co-receptor binding  
enables co-receptor binding  
enables cytokine activity  
enables frizzled binding  
enables frizzled binding PubMed 
enables frizzled binding PubMed 
enables identical protein binding PubMed 
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables receptor ligand activity PubMed 
enables receptor ligand activity  
enables signaling receptor binding  
enables signaling receptor binding PubMed 
enables transcription coactivator activity PubMed 
Items 1 - 25 of 115
Process Evidence Code Pubs
acts_upstream_of B cell proliferation PubMed 
acts_upstream_of_or_within BMP signaling pathway PubMed 
involved_in COP9 signalosome assembly PubMed 
involved_in Wnt signaling pathway PubMed 
acts_upstream_of_or_within Wnt signaling pathway involved in forebrain neuroblast division PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
acts_upstream_of_or_within axis elongation involved in somitogenesis PubMed 
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within axonogenesis PubMed 
acts_upstream_of_or_within axonogenesis PubMed 
involved_in calcium ion transmembrane transport via low voltage-gated calcium channel PubMed 
involved_in canonical Wnt signaling pathway  
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within cardiac muscle cell fate commitment PubMed 
involved_in cardiac muscle cell fate commitment  
involved_in cell fate commitment  
involved_in cell population proliferation  
involved_in cell proliferation in forebrain PubMed 
involved_in cell proliferation in midbrain PubMed 
acts_upstream_of_or_within cell-cell signaling PubMed 
acts_upstream_of cytokine production PubMed 
acts_upstream_of_or_within determination of left/right symmetry PubMed 
involved_in dopaminergic neuron differentiation PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
acts_upstream_of_or_within extracellular matrix organization PubMed 
acts_upstream_of fat cell differentiation PubMed 
acts_upstream_of fat cell differentiation PubMed 
involved_in heart development  
acts_upstream_of_or_within heart looping PubMed 
acts_upstream_of_or_within hemopoiesis PubMed 
acts_upstream_of_or_within hippocampus development PubMed 
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within inner ear morphogenesis PubMed 
acts_upstream_of_or_within mammary gland development PubMed 
acts_upstream_of_or_within mesoderm development PubMed 
involved_in midbrain development PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
acts_upstream_of_or_within myoblast differentiation PubMed 
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance PubMed 
involved_in negative regulation of dopaminergic neuron differentiation PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation PubMed 
involved_in negative regulation of neurogenesis PubMed 
involved_in negative regulation of neuron projection development PubMed 
involved_in neurogenesis PubMed 
involved_in neuron differentiation  
involved_in non-canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within osteoblast differentiation PubMed 
acts_upstream_of_or_within paraxial mesodermal cell fate commitment PubMed 
acts_upstream_of_or_within platelet activation PubMed 
acts_upstream_of_or_within platelet aggregation PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation PubMed 
involved_in positive regulation of DNA-binding transcription factor activity PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of cardiac muscle cell differentiation  
acts_upstream_of positive regulation of cardiac muscle cell differentiation  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin PubMed 
acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity PubMed 
acts_upstream_of_or_within positive regulation of cytokine production PubMed 
involved_in positive regulation of dermatome development  
involved_in positive regulation of dermatome development  
involved_in positive regulation of gene expression  
acts_upstream_of_or_within positive regulation of hepatocyte proliferation PubMed 
involved_in positive regulation of mesodermal cell fate specification  
involved_in positive regulation of mesodermal cell fate specification  
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation  
involved_in positive regulation of protein localization to plasma membrane PubMed 
involved_in positive regulation of protein phosphorylation PubMed 
involved_in positive regulation of protein phosphorylation  
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity PubMed 
involved_in positive regulation of receptor internalization  
involved_in positive regulation of receptor internalization  
involved_in positive regulation of skeletal muscle tissue development PubMed 
acts_upstream_of positive regulation of telomere maintenance via telomerase PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within_positive_effect positive regulation of type B pancreatic cell proliferation PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
acts_upstream_of_or_within protein localization PubMed 
acts_upstream_of_or_within regulation of RNA biosynthetic process PubMed 
acts_upstream_of_or_within regulation of axonogenesis PubMed 
acts_upstream_of_or_within regulation of cell differentiation PubMed 
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization PubMed 
involved_in regulation of postsynapse to nucleus signaling pathway PubMed 
involved_in regulation of postsynapse to nucleus signaling pathway PubMed 
involved_in regulation of presynapse assembly  
involved_in regulation of presynapse assembly  
involved_in regulation of synapse organization  
involved_in secondary palate development  
involved_in secondary palate development  
acts_upstream_of_or_within signal transduction PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation PubMed 
acts_upstream_of_or_within somatic stem cell division PubMed 
acts_upstream_of_or_within somitogenesis PubMed 
acts_upstream_of_or_within spinal cord association neuron differentiation PubMed 
acts_upstream_of_or_within spinal cord association neuron differentiation PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
Items 1 - 25 of 115
Component Evidence Code Pubs
part_of Wnt signalosome PubMed 
part_of Wnt signalosome PubMed 
part_of Wnt-Frizzled-LRP5/6 complex  
part_of Wnt-Frizzled-LRP5/6 complex  
located_in cell surface PubMed 
located_in endoplasmic reticulum lumen  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
is_active_in synapse PubMed 

General protein information

Preferred Names
protein Wnt-3a
Names
vestigial tail
wingless-related MMTV integration site 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009522.3NP_033548.1  protein Wnt-3a precursor

    See identical proteins and their annotated locations for NP_033548.1

    Status: VALIDATED

    Source sequence(s)
    AL713994
    Consensus CDS
    CCDS24766.1
    UniProtKB/Swiss-Prot
    P27467
    Related
    ENSMUSP00000010044.8, ENSMUST00000010044.8
    Conserved Domains (1) summary
    cd19335
    Location:39352
    Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59138859..59181579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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