Wnt10a wingless-type MMTV integration site family, member 10A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt10aprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 10Aprovided by MGI
Primary source: MGI:MGI:108071
See related: Ensembl:ENSMUSG00000026167 AllianceGenome:MGI:108071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within neural crest cell differentiation; positive regulation of gene expression; and regulation of odontogenesis of dentin-containing tooth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 4.4), cortex adult (RPKM 2.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74831178..74843335)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74792019..74804176)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.
Title: Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.
Deficiency of Wnt10a causes female infertility via the beta-catenin/Cyp19a1 pathway in mice.
Title: Deficiency of Wnt10a causes female infertility via the β-catenin/Cyp19a1 pathway in mice.
The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis.
Title: The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis.
This study was the first to histologically evaluate the bone, fat and muscle phenotypes of Wnt10a knockout mice.
Title: Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle.
WNT10a critical role in the stromagenesis and melanoma growth.
Title: Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.
Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4.
Title: WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Deletion of WNT10A resulted in the delayed wound healing associated with suppressed stromagenesis, especially in fibroblasts/myofibroblasts.
Title: Critical in vivo roles of WNT10A in wound healing by regulating collagen expression/synthesis in WNT10A-deficient mice.
The authors conclude that inhibiting DNA methylation by 5-Aza-dC mutual-exclusively regulates the lineage determination of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expression.
Title: Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a.
Wnt10a/beta-catenin signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
Title: Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase.
WNT10A plays an important role in the pathogenesis of IPF via TGF-beta activation and it may also be a sensitive predictor for the onset of an AE-IPF.
Title: Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Wnt10a (e-PCR), detects polymorphism
- UniSTS:465414

Wnt10a (e-PCR), detects polymorphism
- UniSTS:526096

Wnt10a (e-PCR), detects polymorphism
- UniSTS:471320

Wnt10a (e-PCR), detects polymorphism
- UniSTS:527131

U61969 (e-PCR)
- UniSTS:163251

Wnt10a (e-PCR), detects polymorphism
- UniSTS:508406

Wnt10a (e-PCR), detects polymorphism
- UniSTS:508407

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	IDA Inferred from Direct Assay more info	PubMed
involved_in sebaceous gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in tongue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-10a

Names: wingless related MMTV integration site 10a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.