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Wars1 tryptophanyl-tRNA synthetase1 [ Mus musculus (house mouse) ]

Gene ID: 22375, updated on 21-Apr-2024

Summary

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Official Symbol
Wars1provided by MGI
Official Full Name
tryptophanyl-tRNA synthetase1provided by MGI
Primary source
MGI:MGI:104630
See related
Ensembl:ENSMUSG00000021266 AllianceGenome:MGI:104630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WRS; Wars; TrpRS
Summary
Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 173.4), colon adult (RPKM 54.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 59.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108825956..108860095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108860030..108894175, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene predicted gene, 22079 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene brain-enriched guanylate kinase-associated Neighboring gene predicted gene, 52002

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. Paley EL, et al. Neuromolecular Med, 2007. PMID 17114825
  2. An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells. Pajot B, et al. J Mol Biol, 1994 Sep 30. PMID 7932716
  3. Mammalian tryptophanyl-tRNA synthetases. Kisselev LL. Biochimie, 1993. PMID 7515282
  4. Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. Wakasugi K. FEBS Lett, 2010 Jan 4. PMID 19941862
  5. Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Sekita Y, et al. Cytogenet Genome Res, 2006. PMID 16575184

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TrpRS plays a role in protecting against neurodegeneration is suggested, providing an insight into the pathogenesis and a possible treatment of neurodegenerative diseases.
    Title: Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tryptophan-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tryptophan--tRNA ligase, cytoplasmic
Names
tryptophanyl-tRNA synthetase, cytoplasmic
NP_001157786.1
NP_001157960.1
NP_001398836.1
NP_001398837.1
NP_001398838.1
NP_001398839.1
NP_035840.3
XP_006515882.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164314.2 → NP_001157786.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001157786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS49171.1
    UniProtKB/TrEMBL
    Q3U6U7, Q3UDG2
    Related
    ENSMUSP00000105474.4, ENSMUST00000109848.10
    Conserved Domains (3) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:158 → 467
    trpS; tryptophanyl-tRNA synthetase
    pfam00458
    Location:16 → 68
    WHEP-TRS; WHEP-TRS domain

  2. NM_001164488.2 → NP_001157960.1  tryptophan--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001157960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS49171.1
    UniProtKB/TrEMBL
    Q3U6U7, Q3UDG2
    Related
    ENSMUSP00000125320.2, ENSMUST00000161410.8
    Conserved Domains (3) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:158 → 467
    trpS; tryptophanyl-tRNA synthetase
    pfam00458
    Location:16 → 68
    WHEP-TRS; WHEP-TRS domain

  3. NM_001411907.1 → NP_001398836.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    P32921, Q80ZY4, Q99J58, Q9DC65

  4. NM_001411908.1 → NP_001398837.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    P32921, Q80ZY4, Q99J58, Q9DC65

  5. NM_001411909.1 → NP_001398838.1  tryptophan--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 4, 5, and 6 encode the same isoform (1).
    Source sequence(s)
    AC122811, AC152061
    UniProtKB/Swiss-Prot
    P32921, Q80ZY4, Q99J58, Q9DC65

  6. NM_001411910.1 → NP_001398839.1  tryptophan--tRNA ligase, cytoplasmic isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061

  7. NM_011710.4 → NP_035840.3  tryptophan--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_035840.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, and 6 encode the same isoform.
    Source sequence(s)
    AC122811, AC152061
    Consensus CDS
    CCDS26166.1
    UniProtKB/Swiss-Prot
    P32921, Q80ZY4, Q99J58, Q9DC65
    UniProtKB/TrEMBL
    Q4FJZ4
    Related
    ENSMUSP00000124625.2, ENSMUST00000161154.2
    Conserved Domains (2) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:16 → 65
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

RNA

  1. NR_177976.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061

  2. NR_177977.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122811, AC152061

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108825956..108860095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515819.3 → XP_006515882.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006515882.1

    UniProtKB/Swiss-Prot
    P32921, Q80ZY4, Q99J58, Q9DC65
    UniProtKB/TrEMBL
    Q4FJZ4
    Conserved Domains (2) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:16 → 65
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32921.2 GenPept UniProtKB/Swiss-Prot:P32921

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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