Vcl vinculin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vclprovided by MGI
Official Full Name: vinculinprovided by MGI
Primary source: MGI:MGI:98927
See related: Ensembl:ENSMUSG00000021823 AllianceGenome:MGI:98927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9430097D22
Summary: Predicted to enable alpha-catenin binding activity; dystroglycan binding activity; and enzyme binding activity. Acts upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in several cellular components, including costamere; fascia adherens; and focal adhesion. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 91.6), lung adult (RPKM 52.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.53 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20979436..21083744)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20929383..21033676)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biphasic reinforcement of nascent adhesions by vinculin.
Title: Biphasic reinforcement of nascent adhesions by vinculin.
Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis.
Title: Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis.
Focal Adhesion Protein Vinculin Is Required for Proper Meiotic Progression during Mouse Spermatogenesis.
Title: Focal Adhesion Protein Vinculin Is Required for Proper Meiotic Progression during Mouse Spermatogenesis.
Vinculin-mediated axon growth requires interaction with actin but not talin in mouse neocortical neurons.
Title: Vinculin-mediated axon growth requires interaction with actin but not talin in mouse neocortical neurons.
Metavinculin modulates force transduction in cell adhesion sites.
Title: Metavinculin modulates force transduction in cell adhesion sites.
Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections.
Title: Increased talin-vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections.
Vinculins interaction with talin is essential for mammary epithelial differentiation.
Title: Vinculins interaction with talin is essential for mammary epithelial differentiation.
Results identify vinculin as a critical link to contractile actomyosin.
Title: Vinculin anchors contractile actin to the cardiomyocyte adherens junction.
Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction
Title: Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction.
Macrophages use Syk tyrosine kinase signaling to build a mechanosensitive, talin- and vinculin- mediated, focal adhesion-like molecular clutch, which couples integrins to cytoskeletal forces to drive phagocytosis.
Title: Coupling of β(2) integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124252 (e-PCR)
- UniSTS:161074

VCL (e-PCR)
- UniSTS:266571

BARC0060 (e-PCR)
- UniSTS:255337

Vcl (e-PCR), detects polymorphism
- UniSTS:144747

Vcl (e-PCR), detects polymorphism
- UniSTS:144748

AI462105 (e-PCR)
- UniSTS:160366

AW545629 (e-PCR)
- UniSTS:180612

D14Mit50 (e-PCR), detects polymorphism
- UniSTS:127407

D15M14Mit50 (e-PCR)
- UniSTS:239593

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in apical junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to adherens junction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in fascia adherens	IDA Inferred from Direct Assay more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in podosome ring	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
colocalizes_with stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vinculin

Names: metavinculin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.