Vasp vasodilator-stimulated phosphoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vaspprovided by MGI
Official Full Name: vasodilator-stimulated phosphoproteinprovided by MGI
Primary source: MGI:MGI:109268
See related: Ensembl:ENSMUSG00000030403 AllianceGenome:MGI:109268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable SH3 domain binding activity and profilin binding activity. Acts upstream of or within actin cytoskeleton organization; axon guidance; and neural tube closure. Located in filopodium; focal adhesion; and lamellipodium. Is expressed in several structures, including brain and hemolymphoid system gland. Orthologous to human VASP (vasodilator stimulated phosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 234.9), duodenum adult (RPKM 170.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.51 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18990854..19005779, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19256929..19271854, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naive CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo.
Title: Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo.
Vasodilator-stimulated phosphoprotein (VASP) is recruited into dendritic spines via G-actin-dependent mechanism and contributes to spine enlargement and stabilization.
Title: Vasodilator-stimulated phosphoprotein (VASP) is recruited into dendritic spines via G-actin-dependent mechanism and contributes to spine enlargement and stabilization.
Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin.
Title: Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin.
Differential Ser phosphorylation of vasodilator-stimulated phosphoprotein regulates colon tumor formation and growth.
Title: Differential Ser phosphorylation of vasodilator-stimulated phosphoprotein regulates colon tumor formation and growth.
When glucose absorption from the gastrointestinal tract is insufficient to meet body requirements, hepatic gluconeogenesis plays a key role to maintain normal blood glucose levels. These studies investigated the role in this process played by vasodilatory-associated phosphoprotein (VASP), a protein that is phosphorylated in hepatocytes by cAMP/protein kinase A (PKA), a key mediator of the action of glucagon.
Title: The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression.
Myo10kd also inhibited long protrusion (LP) formation by reducing the transportation of its cargo molecule VASP to the leading edge of migrating cells.
Title: Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.
VASP is a major regulator of leukocyte recruitment and polarization in postischemic revascularization and data support a novel role of VASP in chemokine receptor trafficking.
Title: VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.
Myocardial ischemic preconditioning-induced VASP phosphorylation in platelets is a protective mechanism against the deleterious effects of ischemia.
Title: Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning.
VASP selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner.
Title: Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.
We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP
Title: Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasodilator-stimulated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282021.1 → NP_001268950.1 vasodilator-stimulated phosphoprotein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK140329, BB850928, CO040918

UniProtKB/Swiss-Prot

P70460

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:336 → 370

VASP_tetra; VASP tetramerization domain
NM_001282022.1 → NP_001268951.1 vasodilator-stimulated phosphoprotein isoform 3

See identical proteins and their annotated locations for NP_001268951.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AK140329, BB850928, CO040918

UniProtKB/Swiss-Prot

P70460

Conserved Domains (3) summary

cd01207
Location:5 → 104

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08687
Location:235 → 350

ASD2; Apx/Shroom domain ASD2

pfam08776
Location:327 → 361

VASP_tetra; VASP tetramerization domain
NM_009499.3 → NP_033525.2 vasodilator-stimulated phosphoprotein isoform 1

See identical proteins and their annotated locations for NP_033525.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK140329, BB850928, CO040918

Consensus CDS

CCDS52056.1

UniProtKB/Swiss-Prot

P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214

Related

ENSMUSP00000032561.9, ENSMUST00000032561.9

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:337 → 371

VASP_tetra; VASP tetramerization domain

RNA

NR_104069.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two internal exons, and uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.

Source sequence(s)

AK140329, BB850928, CO040918