Trhr thyrotropin releasing hormone receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trhrprovided by MGI
Official Full Name: thyrotropin releasing hormone receptorprovided by MGI
Primary source: MGI:MGI:98824
See related: Ensembl:ENSMUSG00000038760 AllianceGenome:MGI:98824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRH-R1
Summary: Predicted to enable identical protein binding activity and thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within signal transduction. Predicted to be located in cell surface. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skeleton. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 B3.2; 15 16.82 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (44059314..44099308)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (44195924..44235912)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

activating TRH/TRH-R1 signaling seems not to be sufficient for gastric stimulation of acylated ghrelin production
Title: Absence of TRH receptor 1 in male mice affects gastric ghrelin production.
The central nervous systems effects of taltirelin are mediated primarily by TRH-R1 and not TRH-R2.
Title: Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1.
Title: Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.
Direct TRH receptor-mediated excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange.
Title: Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.
A flexible molecular docking procedure revealed that TRH establishes a direct interaction with W6.48 in TRH-R2 but not in TRH-R1.
Title: Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2.
the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways
Title: Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.
Thyrotropin-releasing hormone binding induces separation of cytoplasmic ends of TRH receptor type 1 transmembrane helix 5 (TMH5) and TMH6 and a rotation of TMH6 that could promote interactions between G proteins and key residues within the TRH receptor.
Title: Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches.
three distinct and discontinuous regions of the TSHR (aa 246-260 and 277-296 on the TSHR A subunit) and aa 381-385 (on the TSHR B subunit) fold together to form a complex TSH binding pocket.
Title: Characterization of the thyrotropin binding pocket.
the TSHR may not be similar to other model proteins used to define the concept of central immune tolerance.
Title: Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen.
TRH-R1 has a role in mouse lactation and mice lacking the receptor show signs of central hypothyroidism
Title: Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

Trhr (e-PCR), detects polymorphism
- UniSTS:507405

M94384 (e-PCR)
- UniSTS:125003

Trhr (e-PCR), detects polymorphism
- UniSTS:507288

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyrotropin-releasing hormone receptor

Names: TRH-R; thyroliberin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013696.2 → NP_038724.1 thyrotropin-releasing hormone receptor

See identical proteins and their annotated locations for NP_038724.1

Status: VALIDATED

Source sequence(s)

AC132870, BB653069, BC128269

Consensus CDS

CCDS37068.1

UniProtKB/Swiss-Prot

P21761

UniProtKB/TrEMBL

Q32MS1, Q3UYL6

Related

ENSMUSP00000036320.7, ENSMUST00000038856.14

Conserved Domains (2) summary

pfam00001
Location:42 → 320

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:33 → 165

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

44059314..44099308

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520748.3 → XP_006520811.1 thyrotropin-releasing hormone receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 219

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily