U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tns1 tensin 1 [ Mus musculus (house mouse) ]

Gene ID: 21961, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Tns1provided by MGI
Official Full Name
tensin 1provided by MGI
Primary source
MGI:MGI:104552
See related
Ensembl:ENSMUSG00000055322 AllianceGenome:MGI:104552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tns; 1110018I21Rik; 1200014E20Rik; E030018G17Rik; E030037J05Rik
Summary
Predicted to enable actin binding activity. Acts upstream of or within cell-substrate junction assembly and fibroblast migration. Located in focal adhesion. Is expressed in several structures, including future midbrain; gut; metanephros; nasal process; and yolk sac. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 128.6), bladder adult (RPKM 85.1) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 C3; 1 38.17 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (73949391..74163707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (73910232..74124548, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030407O03 gene Neighboring gene predicted gene 29183 Neighboring gene STARR-seq mESC enhancer starr_01316 Neighboring gene STARR-seq mESC enhancer starr_01317 Neighboring gene STARR-seq mESC enhancer starr_01318 Neighboring gene microRNA 6351 Neighboring gene STARR-seq mESC enhancer starr_01319 Neighboring gene STARR-seq mESC enhancer starr_01321 Neighboring gene predicted gene, 39664 Neighboring gene STARR-positive B cell enhancer ABC_E11074 Neighboring gene VISTA enhancer mm1630 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A role of tensin in skeletal-muscle regeneration. Ishii A, et al. Biochem J, 2001 Jun 15. PMID 11389681, Free PMC Article
  2. Tensin1 positively regulates RhoA activity through its interaction with DLC1. Shih YP, et al. Biochim Biophys Acta, 2015 Dec. PMID 26427649, Free PMC Article
  3. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Chen H, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11792844, Free PMC Article
  4. Progressive kidney degeneration in mice lacking tensin. Lo SH, et al. J Cell Biol, 1997 Mar 24. PMID 9087448, Free PMC Article
  5. Molecular characterization of human tensin. Chen H, et al. Biochem J, 2000 Oct 15. PMID 11023826, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell-substrate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-substrate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tensin-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289895.2 → NP_001276824.1  tensin-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC116419, AC117757
    Consensus CDS
    CCDS48288.2
    UniProtKB/TrEMBL
    A0A087WQS0, A0A1D5RM59
    Related
    ENSMUSP00000140317.2, ENSMUST00000191104.7
    Conserved Domains (5) summary
    cd09927
    Location:1591 → 1706
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:248 → 363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:1728 → 1861
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:350 → 476
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl00040
    Location:75 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  2. NM_001413787.1 → NP_001400716.1  tensin-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC116419, AC117757
    Related
    ENSMUSP00000140254.2, ENSMUST00000187584.7

  3. NM_001413788.1 → NP_001400717.1  tensin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC116419

  4. NM_001413789.1 → NP_001400718.1  tensin-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC116419, AC117757

  5. NM_001413790.1 → NP_001400719.1  tensin-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC116419, AC117757
    Related
    ENSMUSP00000140771.2, ENSMUST00000185331.7

  6. NM_001413791.1 → NP_001400720.1  tensin-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC116419, AC117757

  7. NM_027884.4 → NP_082160.3  tensin-1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC116419, AC117757
    Consensus CDS
    CCDS78614.1
    UniProtKB/Swiss-Prot
    E9Q0S6
    UniProtKB/TrEMBL
    A0A1D5RM59
    Related
    ENSMUSP00000127715.2, ENSMUST00000169786.8
    Conserved Domains (5) summary
    cd09927
    Location:1612 → 1727
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:248 → 363
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:1749 → 1882
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:350 → 476
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl00040
    Location:75 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    73949391..74163707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252982.1 → XP_030108842.1  tensin-1 isoform X8

    UniProtKB/TrEMBL
    A0A1D5RM59
    Conserved Domains (6) summary
    cd09927
    Location:1640 → 1755
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1067 → 1643
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1777 → 1910
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:350 → 476
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:75 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:185 → 343
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_006495871.4 → XP_006495934.1  tensin-1 isoform X7

    UniProtKB/TrEMBL
    A0A1D5RM59
    Conserved Domains (6) summary
    cd09927
    Location:1642 → 1757
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1069 → 1645
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1779 → 1912
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:350 → 476
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:75 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:185 → 343
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_017319864.1 → XP_017175353.1  tensin-1 isoform X15

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (7) summary
    cd09927
    Location:1595 → 1710
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:912 → 1598
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:689 → 1081
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1732 → 1865
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_017319860.1 → XP_017175349.1  tensin-1 isoform X12

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (7) summary
    cd09927
    Location:1603 → 1718
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:912 → 1606
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:689 → 1081
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1740 → 1873
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_017319859.1 → XP_017175348.1  tensin-1 isoform X10

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1616 → 1731
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1043 → 1619
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1753 → 1886
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_036163578.1 → XP_036019471.1  tensin-1 isoform X4

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1636 → 1751
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:964 → 1482
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1773 → 1906
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:61 → 116
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_017319847.1 → XP_017175336.1  tensin-1 isoform X2

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1644 → 1759
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1071 → 1647
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1781 → 1914
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  8. XM_017319866.1 → XP_017175355.1  tensin-1 isoform X23

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (7) summary
    cd09927
    Location:1475 → 1590
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:907 → 1478
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1612 → 1745
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam03154
    Location:580 → 1028
    Atrophin-1; Atrophin-1 family
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  9. XM_030252984.1 → XP_030108844.1  tensin-1 isoform X22

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (7) summary
    cd09927
    Location:1506 → 1621
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:946 → 1509
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1643 → 1776
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam03154
    Location:580 → 1028
    Atrophin-1; Atrophin-1 family
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  10. XM_017319865.1 → XP_017175354.1  tensin-1 isoform X21

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1527 → 1642
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:976 → 1530
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1664 → 1797
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  11. XM_017319863.1 → XP_017175352.1  tensin-1 isoform X14

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (7) summary
    cd09927
    Location:1597 → 1712
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:914 → 1600
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:691 → 1083
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1734 → 1867
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  12. XM_036163588.1 → XP_036019481.1  tensin-1 isoform X11

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1610 → 1725
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1045 → 1613
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1747 → 1880
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:61 → 116
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  13. XM_017319858.1 → XP_017175347.1  tensin-1 isoform X9

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1618 → 1733
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1045 → 1621
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1755 → 1888
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  14. XM_017319856.1 → XP_017175345.1  tensin-1 isoform X6

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1625 → 1740
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:966 → 1471
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1762 → 1895
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  15. XM_017319848.1 → XP_017175337.1  tensin-1 isoform X3

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1638 → 1753
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:966 → 1484
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1775 → 1908
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  16. XM_017319853.1 → XP_017175342.1  tensin-1 isoform X5

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1633 → 1748
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:966 → 1479
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1770 → 1903
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  17. XM_006495867.2 → XP_006495930.2  tensin-1 isoform X1

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1646 → 1761
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1073 → 1649
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1783 → 1916
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:354 → 480
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:79 → 112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:189 → 347
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  18. XM_006495878.4 → XP_006495941.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495941.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  19. XM_017319862.3 → XP_017175351.1  tensin-1 isoform X13

    UniProtKB/TrEMBL
    A0A6I8MWZ2
    Conserved Domains (6) summary
    cd09927
    Location:1622 → 1737
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1049 → 1625
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1759 → 1892
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:330 → 456
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:55 → 88
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:165 → 323
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  20. XM_030252983.1 → XP_030108843.1  tensin-1 isoform X17

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1599 → 1714
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1026 → 1602
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1736 → 1869
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:309 → 435
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:34 → 67
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:144 → 302
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  21. XM_006495872.1 → XP_006495935.1  tensin-1 isoform X16

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (6) summary
    cd09927
    Location:1601 → 1716
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1028 → 1604
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1738 → 1871
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:309 → 435
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl00040
    Location:34 → 67
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl28904
    Location:144 → 302
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  22. XM_006495875.2 → XP_006495938.1  tensin-1 isoform X20

    UniProtKB/TrEMBL
    A0A087WQM0
    Conserved Domains (5) summary
    cd09927
    Location:1553 → 1668
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:980 → 1556
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1690 → 1823
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:261 → 387
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:96 → 254
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  23. XM_036163612.1 → XP_036019505.1  tensin-1 isoform X26

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1482 → 1597
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:810 → 1328
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1619 → 1752
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  24. XM_011238476.3 → XP_011236778.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_011236778.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  25. XM_006495874.4 → XP_006495937.1  tensin-1 isoform X19

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1568 → 1683
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:995 → 1571
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1705 → 1838
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:276 → 402
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:111 → 269
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  26. XM_030252985.2 → XP_030108845.1  tensin-1 isoform X25

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1490 → 1605
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:917 → 1493
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1627 → 1760
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  27. XM_006495877.4 → XP_006495940.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495940.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  28. XM_006495880.4 → XP_006495943.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495943.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  29. XM_006495873.2 → XP_006495936.2  tensin-1 isoform X18

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1552 → 1667
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:979 → 1555
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1689 → 1822
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:260 → 386
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:95 → 253
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  30. XM_011238477.2 → XP_011236779.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_011236779.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  31. XM_006495879.1 → XP_006495942.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495942.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  32. XM_036163609.1 → XP_036019502.1  tensin-1 isoform X24

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  33. XM_006495881.4 → XP_006495944.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495944.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  34. XM_006495882.4 → XP_006495945.1  tensin-1 isoform X24

    See identical proteins and their annotated locations for XP_006495945.1

    UniProtKB/TrEMBL
    A0A087WQ94
    Related
    ENSMUSP00000140094.2, ENSMUST00000185702.7
    Conserved Domains (5) summary
    cd09927
    Location:1492 → 1607
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:919 → 1495
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1629 → 1762
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:200 → 326
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:35 → 193
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  35. XM_030252988.1 → XP_030108848.1  tensin-1 isoform X33

    Conserved Domains (3) summary
    cd09927
    Location:842 → 957
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:274 → 845
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:979 → 1112
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  36. XM_036163624.1 → XP_036019517.1  tensin-1 isoform X32

    Conserved Domains (3) summary
    cd09927
    Location:886 → 1001
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:343 → 889
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1023 → 1156
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  37. XM_030252987.1 → XP_030108847.1  tensin-1 isoform X31

    Conserved Domains (3) summary
    cd09927
    Location:964 → 1079
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:282 → 931
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1101 → 1234
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  38. XM_036163621.1 → XP_036019514.1  tensin-1 isoform X30

    Conserved Domains (3) summary
    cd09927
    Location:977 → 1092
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:412 → 944
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1114 → 1247
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  39. XM_030252986.1 → XP_030108846.1  tensin-1 isoform X29

    Conserved Domains (3) summary
    cd09927
    Location:985 → 1100
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:412 → 952
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1122 → 1255
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  40. XM_036163620.1 → XP_036019513.1  tensin-1 isoform X28

    Conserved Domains (3) summary
    cd09927
    Location:1005 → 1120
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:333 → 851
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1142 → 1275
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

  41. XM_006495883.2 → XP_006495946.1  tensin-1 isoform X27

    Conserved Domains (3) summary
    cd09927
    Location:1013 → 1128
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:440 → 980
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1150 → 1283
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177169.2: Suppressed sequence

    Description
    NM_177169.2: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q0S6.1 GenPept UniProtKB/Swiss-Prot:E9Q0S6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous