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Tln1 talin 1 [ Mus musculus (house mouse) ]

Gene ID: 21894, updated on 21-Apr-2024

Summary

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Official Symbol
Tln1provided by MGI
Official Full Name
talin 1provided by MGI
Primary source
MGI:MGI:1099832
See related
Ensembl:ENSMUSG00000028465 AllianceGenome:MGI:1099832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tln
Summary
Enables integrin binding activity; phosphatidylinositol binding activity; and phosphatidylserine binding activity. Involved in integrin activation and integrin-mediated signaling pathway. Acts upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Located in focal adhesion. Is expressed in several structures, including body cavity or lining; cardiovascular system; neural plate; submandibular gland; and vertebral axis musculature. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 86.9), ovary adult (RPKM 82.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 23.05 cM
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43531513..43562583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43531513..43562583, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene carbonic anhydrase 9 Neighboring gene STARR-positive B cell enhancer ABC_E9584 Neighboring gene tropomyosin 2, beta Neighboring gene STARR-seq mESC enhancer starr_10056 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosidase beta 2 Neighboring gene RAB6A GEF compex partner 1 Neighboring gene microseminoprotein, prostate associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway. Zhang P, et al. Arterioscler Thromb Vasc Biol, 2023 Jun. PMID 37051931
  2. Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity. Latour YL, et al. Gut Microbes, 2023 Jan-Dec. PMID 36951501, Free PMC Article
  3. Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues. Fischer LS, et al. Chembiochem, 2021 Oct 1. PMID 34286903, Free PMC Article
  4. Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding. Zhang P, et al. Proc Natl Acad Sci U S A, 2020 Dec 22. PMID 33288722, Free PMC Article
  5. Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis. Pulous FE, et al. Angiogenesis, 2021 Feb. PMID 33113074, Free PMC Article

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-alpha5beta1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.
    Title: HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling.
  2. Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation.
    Title: Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation.
  3. Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate beta-cell proliferation and mass in mice.
    Title: Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.
  4. AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and alphaIIbbeta3-Mediated Bidirectional Signaling Pathway.
    Title: AGK Potentiates Arterial Thrombosis by Affecting Talin-1 and αIIbβ3-Mediated Bidirectional Signaling Pathway.
  5. Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity.
    Title: Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity.
  6. Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues.
    Title: Peptide-PAINT Enables Investigation of Endogenous Talin with Molecular Scale Resolution in Cells and Tissues.
  7. Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.
    Title: Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.
  8. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
    Title: Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.
  9. Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
    Title: Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
  10. Talin-1 is the principal platelet Rap1 effector of integrin activation.
    Title: Talin-1 is the principal platelet Rap1 effector of integrin activation.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables LIM domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylserine binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-substrate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
talin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011602.5 → NP_035732.2  talin-1

    See identical proteins and their annotated locations for NP_035732.2

    Status: VALIDATED

    Source sequence(s)
    AK122420, AK147228, AL732506, BC121787, CJ242702
    Consensus CDS
    CCDS18101.1
    UniProtKB/Swiss-Prot
    A2AIM8, P26039, Q8VEF0
    UniProtKB/TrEMBL
    Q3UHS6
    Related
    ENSMUSP00000030187.8, ENSMUST00000030187.14
    Conserved Domains (10) summary
    cd12150
    Location:1654 → 1826
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88 → 313
    B41; Band 4.1 homologues
    smart00307
    Location:2336 → 2532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309 → 400
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:204 → 313
    FERM_M; FERM central domain
    pfam08913
    Location:1849 → 1973
    VBS; Vinculin Binding Site
    pfam09141
    Location:491 → 652
    Talin_middle; Talin, middle domain
    pfam09379
    Location:90 → 186
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 83
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:822 → 912
    I_LWEQ; I/LWEQ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43531513..43562583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537770.4 → XP_006537833.1  talin-1 isoform X3

    See identical proteins and their annotated locations for XP_006537833.1

    UniProtKB/TrEMBL
    Q3UHS6
    Conserved Domains (9) summary
    cd12150
    Location:1671 → 1843
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88 → 313
    B41; Band 4.1 homologues
    smart00307
    Location:2353 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309 → 400
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1866 → 1990
    VBS; Vinculin Binding Site
    cd17171
    Location:2 → 85
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:86 → 197
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:491 → 652
    Talin_middle; Talin, middle domain
    cl19756
    Location:839 → 935
    I_LWEQ; I/LWEQ domain

  2. XM_006537769.4 → XP_006537832.3  talin-1 isoform X2

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (9) summary
    cd12150
    Location:1723 → 1895
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157 → 382
    B41; Band 4.1 homologues
    smart00307
    Location:2405 → 2601
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378 → 469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1918 → 2042
    VBS; Vinculin Binding Site
    cd17171
    Location:71 → 154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155 → 266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560 → 721
    Talin_middle; Talin, middle domain
    cl19756
    Location:891 → 987
    I_LWEQ; I/LWEQ domain

  3. XM_006537768.4 → XP_006537831.3  talin-1 isoform X1

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (9) summary
    cd12150
    Location:1740 → 1912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157 → 382
    B41; Band 4.1 homologues
    smart00307
    Location:2422 → 2618
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378 → 469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1935 → 2059
    VBS; Vinculin Binding Site
    cd17171
    Location:71 → 154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155 → 266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560 → 721
    Talin_middle; Talin, middle domain
    cl19756
    Location:908 → 1004
    I_LWEQ; I/LWEQ domain

  4. XM_036163963.1 → XP_036019856.1  talin-1 isoform X5

    UniProtKB/TrEMBL
    Q3UHS6
    Conserved Domains (7) summary
    cd12150
    Location:1383 → 1555
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2065 → 2261
    ILWEQ; I/LWEQ domain
    cd10569
    Location:21 → 112
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1578 → 1702
    VBS; Vinculin Binding Site
    pfam09141
    Location:203 → 364
    Talin_middle; Talin, middle domain
    cl09511
    Location:1 → 25
    FERM_B-lobe; FERM domain B-lobe
    cl19756
    Location:551 → 647
    I_LWEQ; I/LWEQ domain

  5. XM_036163962.1 → XP_036019855.1  talin-1 isoform X4

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (8) summary
    cd12150
    Location:1740 → 1912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157 → 382
    B41; Band 4.1 homologues
    cd10569
    Location:378 → 469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1935 → 2059
    VBS; Vinculin Binding Site
    cd17171
    Location:71 → 154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155 → 266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560 → 721
    Talin_middle; Talin, middle domain
    cl19756
    Location:908 → 1004
    I_LWEQ; I/LWEQ domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26039.2 GenPept UniProtKB/Swiss-Prot:P26039

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