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Polr3a polymerase (RNA) III (DNA directed) polypeptide A [ Mus musculus (house mouse) ]

Gene ID: 218832, updated on 11-Apr-2024

Summary

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Official Symbol
Polr3aprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Aprovided by MGI
Primary source
MGI:MGI:2681836
See related
Ensembl:ENSMUSG00000025280 AllianceGenome:MGI:2681836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPC1; RPC155; 9330175N20Rik
Summary
Enables chromatin binding activity. Predicted to be involved in innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism and progeria. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.4), cerebellum adult (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 14.4 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (24498762..24537126, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (24448694..24487070, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36194 Neighboring gene predicted gene, 41109 Neighboring gene predicted gene, 52167 Neighboring gene predicted gene, 47814 Neighboring gene STARR-seq mESC enhancer starr_36195 Neighboring gene ribosomal protein S24 Neighboring gene predicted gene, 31720

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. Choquet K, et al. Mol Brain, 2019 Jun 20. PMID 31221184, Free PMC Article
  2. Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Choquet K, et al. Mol Brain, 2017 Apr 13. PMID 28407788, Free PMC Article
  3. A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Canella D, et al. Genome Res, 2012 Apr. PMID 22287103, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC62420

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-directed 5'-3' RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA/RNA hybrid binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC1
NP_001074716.1
XP_036014446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081247.2 → NP_001074716.1  DNA-directed RNA polymerase III subunit RPC1

    See identical proteins and their annotated locations for NP_001074716.1

    Status: VALIDATED

    Source sequence(s)
    AC154573
    Consensus CDS
    CCDS36828.1
    UniProtKB/TrEMBL
    B2RXC6
    Related
    ENSMUSP00000026322.8, ENSMUST00000026322.9
    Conserved Domains (4) summary
    cd02736
    Location:1021 → 1360
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    PRK08566
    Location:7 → 932
    PRK08566; DNA-directed RNA polymerase subunit A'; Validated
    cd02583
    Location:24 → 891
    RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain
    pfam04998
    Location:841 → 1317
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    24498762..24537126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158553.1 → XP_036014446.1  DNA-directed RNA polymerase III subunit RPC1 isoform X1

    Conserved Domains (3) summary
    cd02736
    Location:376 → 715
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    CHL00117
    Location:196 → 413
    rpoC2; RNA polymerase beta'' subunit; Reviewed
    cl19114
    Location:1 → 246
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183157.1: Suppressed sequence

    Description
    NM_183157.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version

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