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Timp1 tissue inhibitor of metalloproteinase 1 [ Mus musculus (house mouse) ]

Gene ID: 21857, updated on 5-Mar-2024

Summary

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Official Symbol
Timp1provided by MGI
Official Full Name
tissue inhibitor of metalloproteinase 1provided by MGI
Primary source
MGI:MGI:98752
See related
Ensembl:ENSMUSG00000001131 AllianceGenome:MGI:98752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPA; Clgi; Timp; TIMP-1; TPA-S1
Summary
Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 113.3), adrenal adult (RPKM 13.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.3; X 16.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20736524..20740972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20870166..20874737)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Araf proto-oncogene, serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1532 Neighboring gene ribonuclease UK114 pseudogene Neighboring gene microRNA 5617 Neighboring gene synapsin I Neighboring gene STARR-seq mESC enhancer starr_46887 Neighboring gene STARR-seq mESC enhancer starr_46888 Neighboring gene complement factor properdin Neighboring gene ELK1, member of ETS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and differentiation of osteoclasts by targeting the AKT pathway. Xi Y, et al. Exp Cell Res, 2020 Apr 15. PMID 32113948
  2. AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice. Remes A, et al. J Heart Lung Transplant, 2020 Apr. PMID 32035727
  3. TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms. Knight BE, et al. Front Mol Neurosci, 2019. PMID 31616247, Free PMC Article
  4. TIMP-1 Promotes the Immune Response in Influenza-Induced Acute Lung Injury. Allen JR, et al. Lung, 2018 Dec. PMID 30167842, Free PMC Article
  5. Adeno-Associated Virus-Mediated Gene Transfer of Tissue Inhibitor of Metalloproteinases-1 Impairs Neutrophil Extracellular Trap Formation and Ameliorates Hepatic Ischemia and Reperfusion Injury. Duarte S, et al. Am J Pathol, 2018 Aug. PMID 29870740, Free PMC Article

See all (277) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
    Title: Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
  2. RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-kappaB signaling pathway.
    Title: RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway.
  3. The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
    Title: The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
  4. CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
    Title: CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
  5. siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
    Title: siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
  6. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
    Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
  7. Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
    Title: Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
  8. Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
    Title: Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
  9. The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathy.
    Title: The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathy.
  10. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.
    Title: TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (119)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC7143

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metalloproteinase inhibitor 1
Names
TPA-induced protein
collagenase inhibitor 16C8 fibroblast
erythroid-potentiating activity
tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044384.2 → NP_001037849.1  metalloproteinase inhibitor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001037849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL671885
    Consensus CDS
    CCDS30046.1
    UniProtKB/Swiss-Prot
    P12032, P20064, Q61720
    Related
    ENSMUSP00000009530.5, ENSMUST00000009530.5
    Conserved Domains (1) summary
    smart00206
    Location:25 → 199
    NTR; Tissue inhibitor of metalloproteinase family

  2. NM_001294280.3 → NP_001281209.1  metalloproteinase inhibitor 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
    Source sequence(s)
    AL671885
    Conserved Domains (1) summary
    cl02512
    Location:1 → 131
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  3. NM_001426018.1 → NP_001412947.1  metalloproteinase inhibitor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL671885

  4. NM_001426019.1 → NP_001412948.1  metalloproteinase inhibitor 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL671885

  5. NM_001426020.1 → NP_001412949.1  metalloproteinase inhibitor 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL671885

  6. NM_011593.3 → NP_035723.2  metalloproteinase inhibitor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_035723.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL671885
    Consensus CDS
    CCDS30046.1
    UniProtKB/Swiss-Prot
    P12032, P20064, Q61720
    Related
    ENSMUSP00000110999.4, ENSMUST00000115342.10
    Conserved Domains (1) summary
    smart00206
    Location:25 → 199
    NTR; Tissue inhibitor of metalloproteinase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20736524..20740972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12032.2 GenPept UniProtKB/Swiss-Prot:P12032

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