Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tial1provided by MGI
Official Full Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1provided by MGI
Primary source: MGI:MGI:107913
See related: Ensembl:ENSMUSG00000030846 AllianceGenome:MGI:107913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIAR; mTIAR; 5330433G13Rik
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within germ cell development; positive regulation of cell population proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; and trunk. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 23.5), CNS E14 (RPKM 22.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 70.2 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (128041496..128063450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128439772..128461726, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis.
Title: The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis.
Silencing of TIAR in chronic myeloid leukemia cells strongly elevated BRCA1.
Title: Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.
Title: Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression.
Either TIA1 or TIAR inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.
Title: T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy.
study reports the importance of the tightly balanced expression of the RNA-binding protein TIAR for normal embryonic development, thereby emphasizing the role of post-transcriptional regulations in early embryonic programming
Title: Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.
SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR) and has a role in impaired post-transcriptional regulation of vascular endothelial growth factor
Title: Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor.
TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2
Title: TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.
The intronic splicing enhancer of minute virus of mice binds the cellular RNA-processing proteins TIA-1 and TIAR, which enhance usage of the nonconsensus donor.
Title: Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.
TIAR regulates the relative expression of TIA-1 isoforms.
Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
in addition to transcriptional regulation, another mechanism by which apigenin prevents COX-2 expression is through mediating TIAR suppression of translatino
Title: Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tial1 (e-PCR), detects polymorphism
- UniSTS:479295

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleolysin TIAR

Names: TIA-1-related protein; Tial1 cytotoxic granule-associated RNA binding protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347640.1 → NP_001334569.1 nucleolysin TIAR isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC130474

Consensus CDS

CCDS85429.1

UniProtKB/TrEMBL

Q921W2

Related

ENSMUSP00000033135.8, ENSMUST00000033135.9

Conserved Domains (3) summary

cd12620
Location:205 → 277

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12616
Location:10 → 90

RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins

cd12617
Location:96 → 175

RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins
NM_001347641.1 → NP_001334570.1 nucleolysin TIAR isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AC130474

Consensus CDS

CCDS85428.1

UniProtKB/TrEMBL

D3Z3Y4, Q6NVC2

Related

ENSMUSP00000101835.3, ENSMUST00000106228.8

Conserved Domains (3) summary

cd12620
Location:166 → 238

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12617
Location:57 → 136

RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

cl17169
Location:1 → 51

RRM_SF; RNA recognition motif (RRM) superfamily
NM_009383.2 → NP_033409.1 nucleolysin TIAR isoform 1

See identical proteins and their annotated locations for NP_033409.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC130474, AK012085

Consensus CDS

CCDS21897.1

UniProtKB/Swiss-Prot

P70318

UniProtKB/TrEMBL

Q545C1

Related

ENSMUSP00000101833.3, ENSMUST00000106226.9

Conserved Domains (3) summary

cd12620
Location:222 → 294

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12616
Location:10 → 107

RRM1_TIAR; RNA recognition motif 1 (RRM1) found in nucleolysin TIAR and similar proteins

cd12617
Location:113 → 192

RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

128041496..128063450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507571.4 → XP_006507634.1 nucleolysin TIAR isoform X1

See identical proteins and their annotated locations for XP_006507634.1

Conserved Domains (3) summary

cd12620
Location:183 → 255

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cd12617
Location:74 → 153

RRM2_TIAR; RNA recognition motif 2 (RRM2) found in nucleolysin TIAR and similar proteins

cl17169
Location:19 → 68

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036152887.1 → XP_036008780.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242350.1 → XP_030098210.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242352.1 → XP_030098212.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036152890.1 → XP_036008783.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036152888.1 → XP_036008781.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242349.2 → XP_030098209.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Related

ENSMUSP00000145933.2, ENSMUST00000141126.8

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242346.2 → XP_030098206.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242353.2 → XP_030098213.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242351.2 → XP_030098211.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017322108.3 → XP_017177597.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242348.2 → XP_030098208.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030242354.2 → XP_030098214.1 nucleolysin TIAR isoform X2

UniProtKB/TrEMBL

A0A0U1RPD3

Conserved Domains (2) summary

cd12620
Location:82 → 154

RRM3_TIAR; RNA recognition motif 3 (RRM3) found in nucleolysin TIAR and similar proteins

cl17169
Location:2 → 52

RRM_SF; RNA recognition motif (RRM) superfamily