Thrb thyroid hormone receptor beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thrbprovided by MGI
Official Full Name: thyroid hormone receptor betaprovided by MGI
Primary source: MGI:MGI:98743
See related: Ensembl:ENSMUSG00000021779 AllianceGenome:MGI:98743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta
Summary: Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 2.1), adrenal adult (RPKM 2.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 7.08 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (4429599..4810538, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (17659225..18040097)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.
Title: Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.
Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.
Title: Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.
Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production.
Title: Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.
Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways.
Title: Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion
Title: Thyroid hormone receptor β1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice.
Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice.
Title: Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling.
Genetic Repression in Hypothyroidism Is Mediated by Thrb1.
Title: NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Title: Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
TRbeta protein, target gene expression, and metabolic adaptive changes can occur in individual tissues without necessarily being reflected by circulating TH and TSH concentrations
Title: Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Using domain exchanges and individual amino acid switches between THRA1 and THRB2, three amino acids were identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1.
Title: Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation.

Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (17) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Thrb (e-PCR), detects polymorphism
- UniSTS:532522

NoName (e-PCR)
- UniSTS:490800

Thrb (e-PCR), detects polymorphism
- UniSTS:547400

D14Mit220 (e-PCR), detects polymorphism
- UniSTS:127334

Thrb (e-PCR), detects polymorphism
- UniSTS:463228

Thrb (e-PCR), detects polymorphism
- UniSTS:265614

PMC27204P1 (e-PCR)
- UniSTS:272380

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid hormone mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal cone cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of retinal cone cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type I pneumocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: thyroid hormone receptor beta

Names: TR beta; c-erbA-2; c-erbA-beta; nuclear receptor subfamily 1 group A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113417.2 → NP_001106888.1 thyroid hormone receptor beta isoform 1

See identical proteins and their annotated locations for NP_001106888.1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

Consensus CDS

CCDS49404.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Related

ENSMUSP00000022303.10, ENSMUST00000022303.17

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
NM_001424663.1 → NP_001411592.1 thyroid hormone receptor beta isoform 3

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039
NM_001424664.1 → NP_001411593.1 thyroid hormone receptor beta isoform 1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80
NM_001424665.1 → NP_001411594.1 thyroid hormone receptor beta isoform 1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80
NM_001424666.1 → NP_001411595.1 thyroid hormone receptor beta isoform 1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80
NM_001424667.1 → NP_001411596.1 thyroid hormone receptor beta isoform 1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80
NM_001424668.1 → NP_001411597.1 thyroid hormone receptor beta isoform 1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, AC161609, AC163039

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80
NM_009380.3 → NP_033406.1 thyroid hormone receptor beta isoform 2

See identical proteins and their annotated locations for NP_033406.1

Status: VALIDATED

Source sequence(s)

AC154626, AC154681, BC089035

Consensus CDS

CCDS26835.1

UniProtKB/TrEMBL

Q3UZT5

Related

ENSMUSP00000022304.11, ENSMUST00000022304.12

Conserved Domains (2) summary

cd06935
Location:230 → 472

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:120 → 206

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

4429599..4810538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158539.1 → XP_036014432.1 thyroid hormone receptor beta isoform X2

UniProtKB/TrEMBL

Q3UZT5

Conserved Domains (2) summary

cd06935
Location:185 → 427

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:75 → 161

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_036158537.1 → XP_036014430.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_011244741.4 → XP_011243043.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_011243043.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_011244743.4 → XP_011243045.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_011243045.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_011244740.4 → XP_011243042.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_011243042.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_006517972.5 → XP_006518035.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_006518035.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_006517971.5 → XP_006518034.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_006518034.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_006517970.5 → XP_006518033.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_006518033.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_006517967.5 → XP_006518030.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_006518030.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_011244737.3 → XP_011243039.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_011243039.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_011244742.3 → XP_011243044.1 thyroid hormone receptor beta isoform X1

See identical proteins and their annotated locations for XP_011243044.1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_030247720.2 → XP_030103580.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_036158536.1 → XP_036014429.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P37242, P37244, Q0VDR8, Q3TY80

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers