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Eif5 eukaryotic translation initiation factor 5 [ Mus musculus (house mouse) ]

Gene ID: 217869, updated on 5-Mar-2024

Summary

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Official Symbol
Eif5provided by MGI
Official Full Name
eukaryotic translation initiation factor 5provided by MGI
Primary source
MGI:MGI:95309
See related
Ensembl:ENSMUSG00000021282 AllianceGenome:MGI:95309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D12Ertd549e; 2810011H21Rik
Summary
Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Predicted to be involved in activation of GTPase activity; cytoplasmic translational initiation; and regulation of translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and retina nuclear layer. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 62.4), CNS E11.5 (RPKM 53.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eif5 in Genome Data Viewer
Location:
12 F1; 12 61.03 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111504535..111513187)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111538101..111546753)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor, alpha-induced protein 2 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266 Neighboring gene STARR-positive B cell enhancer ABC_E138 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene RIKEN cDNA 2810029C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E7187 Neighboring gene MAP/microtubule affinity regulating kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos. De Sousa PA, et al. Biol Reprod, 1998 Oct. PMID 9746750
  2. Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Capriati M, et al. Sci Rep, 2023 May 17. PMID 37198424, Free PMC Article
  3. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Kraushar ML, et al. Proc Natl Acad Sci U S A, 2014 Sep 9. PMID 25157170, Free PMC Article
  4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36374, MGC36509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic initiation factor eIF2 binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 5
Names
eIF-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173363.5 → NP_775539.1  eukaryotic translation initiation factor 5

    See identical proteins and their annotated locations for NP_775539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represent the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI391022, AK160828, AK163368, AW547465
    Consensus CDS
    CCDS26180.1
    UniProtKB/Swiss-Prot
    P59325
    UniProtKB/TrEMBL
    Q3TKY2, Q3TQR3
    Related
    ENSMUSP00000126825.2, ENSMUST00000166123.9
    Conserved Domains (2) summary
    cd11561
    Location:231 → 383
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

  2. NM_178041.2 → NP_829887.1  eukaryotic translation initiation factor 5

    See identical proteins and their annotated locations for NP_829887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI391022, AK159232, AK160828, AW547465
    Consensus CDS
    CCDS26180.1
    UniProtKB/Swiss-Prot
    P59325
    UniProtKB/TrEMBL
    Q3TKY2, Q3TQR3
    Related
    ENSMUSP00000152791.2, ENSMUST00000222375.2
    Conserved Domains (2) summary
    cd11561
    Location:231 → 383
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111504535..111513187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59325.1 GenPept UniProtKB/Swiss-Prot:P59325

Gene LinkOut

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