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Ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Mus musculus (house mouse) ]

Gene ID: 21770, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp2r5dprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', deltaprovided by MGI
Primary source
MGI:MGI:2388481
See related
Ensembl:ENSMUSG00000059409 AllianceGenome:MGI:2388481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex271; B'delta; TEG-271
Summary
Predicted to enable phosphoprotein phosphatase activity and protein phosphatase activator activity. Acts upstream of or within positive regulation of protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; ovary; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 36.1), CNS E11.5 (RPKM 34.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 22.9 cM; 17 C
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46993917..47015952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46682991..46705026, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene kelch domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene male enhanced antigen 1 Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo. Lambrecht C, et al. Oncogene, 2018 Jan 25. PMID 28967903
  2. Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. Ahn JH, et al. PLoS One, 2011. PMID 22046270, Free PMC Article
  3. Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. Ortega-Lázaro JC, et al. Cytogenet Genome Res, 2003. PMID 15051958
  4. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Louis JV, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21482799, Free PMC Article
  5. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. Kapfhamer D, et al. J Neurosci, 2010 Jun 30. PMID 20592205, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ppp2r5d knockout mice are predisposed to spontaneous tumor development, providing the first in vivo evidence that validates a single PP2A complex as a bona fide tumor suppressor.
    Title: Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.
  2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.
    Title: MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.
  3. activation of the B56delta-containing heterotrimeric form of PP2A is responsible for enhanced dephosphorylation of Ser40 of tyrosine hydroylase in response to stimulation of PKC
    Title: Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A.
  4. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
    Title: Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
  5. A comparative expression study of Ppp2r5d and Mea1 in spermatogenesis.
    Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Names
testis expressed gene 271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357684.1 → NP_001344613.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    BE948258, CT030702
    Consensus CDS
    CCDS89107.1
    UniProtKB/TrEMBL
    Q7TNL5, Q99PC9
    Related
    ENSMUSP00000156500.2, ENSMUST00000233988.2
    Conserved Domains (2) summary
    pfam01603
    Location:101 → 506
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:49 → 115
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

  2. NM_009358.3 → NP_033384.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1

    See identical proteins and their annotated locations for NP_033384.2

    Status: VALIDATED

    Source sequence(s)
    AK160587, CJ042073, CT030702
    Consensus CDS
    CCDS28836.1
    UniProtKB/TrEMBL
    Q91V89, Q99PC9
    Related
    ENSMUSP00000002839.9, ENSMUST00000002839.9
    Conserved Domains (2) summary
    pfam01603
    Location:100 → 505
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:48 → 114
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46993917..47015952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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