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Taok1 TAO kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 216965, updated on 11-Apr-2024

Summary

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Official Symbol
Taok1provided by MGI
Official Full Name
TAO kinase 1provided by MGI
Primary source
MGI:MGI:1914490
See related
Ensembl:ENSMUSG00000017291 AllianceGenome:MGI:1914490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psk2; Markk; Map3k16; 2810468K05Rik; D130018F14Rik
Summary
Predicted to enable several functions, including cytoskeletal protein binding activity; protein C-terminus binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of JNK cascade; and regulation of cytoskeleton organization. Predicted to act upstream of or within DNA repair and apoptotic process. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; lung; nervous system; and retina. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.8), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.64 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77419988..77516185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77529162..77625359, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene predicted gene 10392 Neighboring gene abhydrolase domain containing 15 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8973 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase. Beeman N, et al. Sci Signal, 2023 Jan 3. PMID 36595571, Free PMC Article
  2. TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development. van Woerden GM, et al. Hum Mutat, 2021 Apr. PMID 33565190, Free PMC Article
  3. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Draviam VM, et al. Nat Cell Biol, 2007 May. PMID 17417629
  4. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. Gunther CV, et al. Genes Dev, 1990 Apr. PMID 2163347
  5. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. Hutchison M, et al. J Biol Chem, 1998 Oct 30. PMID 9786855

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
    Title: Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
  2. Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
    Title: Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
  3. Isolation and functional characterization of the rat Taok1 ortholog, and comparison to human TAOK1.
    Title: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.
  4. Functional analysis of the human Tao1 ortholog.
    Title: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29021, mKIAA1361

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase TAO1
Names
serine/threonine protein kinase TAO1 homolog
thousand and one amino acid protein 1
NP_001351062.1
NP_001351063.1
NP_659074.2
XP_006533022.1
XP_006533023.1
XP_011247232.1
XP_030101697.1
XP_036012472.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364133.1 → NP_001351062.1  serine/threonine-protein kinase TAO1

    Status: VALIDATED

    Source sequence(s)
    AL591136
    Consensus CDS
    CCDS36235.1
    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  2. NM_001364134.1 → NP_001351063.1  serine/threonine-protein kinase TAO1

    Status: VALIDATED

    Source sequence(s)
    AL591136
    Consensus CDS
    CCDS36235.1
    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  3. NM_144825.3 → NP_659074.2  serine/threonine-protein kinase TAO1

    See identical proteins and their annotated locations for NP_659074.2

    Status: VALIDATED

    Source sequence(s)
    AK013386, AK143530, AK173156, BC034906, BE691513, CF164486, CN717576, CN717636, CN718413, CN721819, CN724017, CN724388
    Consensus CDS
    CCDS36235.1
    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Related
    ENSMUSP00000055470.8, ENSMUST00000058496.8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77419988..77516185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245837.2 → XP_030101697.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Related
    ENSMUSP00000017435.5, ENSMUST00000017435.11
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  2. XM_011248930.4 → XP_011247232.1  serine/threonine-protein kinase TAO1 isoform X1

    See identical proteins and their annotated locations for XP_011247232.1

    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  3. XM_006532960.4 → XP_006533023.1  serine/threonine-protein kinase TAO1 isoform X2

    Conserved Domains (3) summary
    COG0419
    Location:194 → 625
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl21453
    Location:11 → 70
    PKc_like; Protein Kinases, catalytic domain
    cl27706
    Location:656 → 713
    Prion; Prion/Doppel alpha-helical domain

  4. XM_006532959.5 → XP_006533022.1  serine/threonine-protein kinase TAO1 isoform X1

    See identical proteins and their annotated locations for XP_006533022.1

    UniProtKB/Swiss-Prot
    Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
    UniProtKB/TrEMBL
    B2RX66
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  5. XM_036156579.1 → XP_036012472.1  serine/threonine-protein kinase TAO1 isoform X2

    Conserved Domains (3) summary
    COG0419
    Location:194 → 625
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl21453
    Location:11 → 70
    PKc_like; Protein Kinases, catalytic domain
    cl27706
    Location:656 → 713
    Prion; Prion/Doppel alpha-helical domain

RNA

  1. XR_004936918.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F2E8.1 GenPept UniProtKB/Swiss-Prot:Q5F2E8

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