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Papolg poly(A) polymerase gamma [ Mus musculus (house mouse) ]

Gene ID: 216578, updated on 11-Apr-2024

Summary

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Official Symbol
Papolgprovided by MGI
Official Full Name
poly(A) polymerase gammaprovided by MGI
Primary source
MGI:MGI:2442119
See related
Ensembl:ENSMUSG00000020273 AllianceGenome:MGI:2442119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630006B20Rik
Summary
Predicted to enable metal ion binding activity and polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Orthologous to human PAPOLG (poly(A) polymerase gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 4.0), CNS E11.5 (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Papolg in Genome Data Viewer
Location:
11 A3.2; 11 14.37 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23810145..23845292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23860145..23895293, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticuloendotheliosis oncogene Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612 Neighboring gene STARR-seq mESC enhancer starr_28925 Neighboring gene STARR-positive B cell enhancer mm9_chr11:23795118-23795419 Neighboring gene STARR-seq mESC enhancer starr_28926 Neighboring gene predicted gene 12061 Neighboring gene STARR-seq mESC enhancer starr_28927 Neighboring gene STARR-seq mESC enhancer starr_28928 Neighboring gene RIKEN cDNA A830031A19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:23949249-23949549 Neighboring gene STARR-positive B cell enhancer mm9_chr11:23977830-23978131 Neighboring gene predicted gene, 57804 Neighboring gene STARR-seq mESC enhancer starr_28930 Neighboring gene STARR-seq mESC enhancer starr_28931 Neighboring gene BCL11 transcription factor A Neighboring gene STARR-positive B cell enhancer ABC_E9360 Neighboring gene RIKEN cDNA 4930538E20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(A) polymerase gamma
Names
PAP-gamma
SRP 3'-adenylating protein
SRP RNA 3'-adenylating enzyme
SRP RNA-adenylating enzyme
polynucleotide adenylyltransferase gamma
signal recognition particle RNA-adenylating enzyme
NP_766143.2
XP_006514716.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172555.2 → NP_766143.2  poly(A) polymerase gamma

    See identical proteins and their annotated locations for NP_766143.2

    Status: VALIDATED

    Source sequence(s)
    AK035810, BC023030, CJ075859, DQ103505
    Consensus CDS
    CCDS24481.1
    UniProtKB/Swiss-Prot
    Q6PCL9, Q8BZC9
    Related
    ENSMUSP00000020513.4, ENSMUST00000020513.10
    Conserved Domains (3) summary
    PTZ00418
    Location:3 → 569
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:365 → 504
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20 → 363
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23810145..23845292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514653.5 → XP_006514716.1  poly(A) polymerase gamma isoform X1

    Conserved Domains (3) summary
    PTZ00449
    Location:481 → 715
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam04926
    Location:357 → 495
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:12 → 354
    PAP_central; Poly(A) polymerase central domain

RNA

  1. XR_380964.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCL9.1 GenPept UniProtKB/Swiss-Prot:Q6PCL9

Gene LinkOut

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